The Significance Of MiR-194 In The Recurrence Of Advanced Colorectal Adenoma

Aims:This article is aimed to investigate the expression of miR-194 in the mucosa of advanced colorectal adenoma.Through follow-up of patients with advanced colorectal adenoma,this article discusses about the relationship between the expression of miR-194 and the recurrence rates of colorectal adenoma.Methods:128 patients diagnosed with advanced colorectal adenoma by colonoscopy with biopsy in Renji Hospital,Shanghai,from Jan 1^st,2008 to Dec 31^th,were recruited in this study,and were followed for 6 years.miR-194 level in the mucosa of the lesions of advanced colorectal adenoma was decided using the technique of in-situ hybridization.The relationship between the expression of miR-194 and the recurrence rates of colorectal adenoma was assessed.Results:The follow-up shows elderly patients are more likely to experience adenoma recurrence（P=0.019）.The 3 criteria for the diagnosis for advanced colorectal adenoma–（1）diameter≥10mm;（2）with high-grade intraepithelial neoplasia or severe dysplasia;（3）with villous components（tubulovillous or villous）–are all positively correlated with the recurrence of adenomas（P=0.000,0.001,0.028,respectively）.The expression level of miR-194 in the mucosa of advanced colorectal adenoma patients who had recurrence during the follow-up time is significantly lower than the miR-194 level in patients who have not recurred during that time（P=0.0012）.Conclusions:The results indicated that the level of miR-194expression decreases in advanced colorectal adenoma of patients who had recurrence of adenoma during follow-up period,as well as that patients with low miR-194 expression are more likely to develop adenomas repeatedly in the long run.The results of this study shows that miR-194 might have a role in the progression of colorectal mucosal hyperplasia and advanced colorectal adenoma,and it may act as a factor in the evaluation of the risks for the recurrence of advanced colorectal adenoma.miR-194 may be used to predict whether certain advanced colorectal adenoma is prone to recur after treatments.