Study On The Changes Of White Matter Fiber In Children With Benign Epilepsy Based On Automating Fiber-tract Quantification

Part Ⅰ: Study on the changes of white matter fiber in children with CAE based on automating fiber-tract quantificationPurpose: Childhood absence epilepsy(CAE)is the most common comprehensive epilepsy syndrome in childhood.The previous view is that the prognosis of the disease is well,and the children will not leave obvious residual symptoms.However,more and more studies have shown that CAE children have abnormalities in memory function,linguistic function and behavior.In this paper,the integrity changes of white matter fibers in children with CAE are discussed in order to understand the possible mechanism of cognitive impairment in children with CAE.Method: We collected 29 cases of CAE children and 24 healthy children with the same age and sex as the control group.We obtained their magnetic resonance dispersion tensor imaging data by 3.0T MRI.We used AFQ software to extract the main 20 fiber bundles in the brain.All fiber bundles were divided into 100 nodes,FA,MD,AD and RD were extracted from each node.Independent sample t-test and multiple comparison and correction were used to compare the differences of each node.Tested the average FA,MD,AD and RD,and comparing the differences between CAE group and control group.According to the course of disease,the CAE group was divided into early group(less than or equal to 6 months)and late group(more than 6 months),comparing the differences between the two groups.Result: A total of 18 main fiber bundles in the brain were extracted in this test,and the FA of CAE children was decreased in most fiber bundles,the MD and RD increased,and the change of AD was not detected,especially in uncinate and arcuate.For the disease group,no significant differences between the early group and the late group have been found.Conclusion: The study suggests that there is a wide range of white matter fiber damage in the brain of CAE children,with the most significant damage of uncinate and arcuate.The result provides a structural basis for revealing cognitive impairment in children with CAE.Part Ⅱ: Study on the changes of white matter fiber in children with BECTS based on automating fiber-tract quantificationPurpose: Benign epilepsy of childhood with centrotemporal spikes(BECTS)is the most common idiopathic focal age-dependent epilepsy syndrome in childhood.BECTS has been considered to be benign epilepsy with a good prognosis,but more and more studies have shown that there is at least one abnormality in cognitive function,linguistic function and motor function in children with BECTS.In this paper,the integrity changes of white matter fibers in children with BECTS are discussed in order to understand the possible mechanism of cognitive impairment in children with BECTS.Method:We collected 26 cases of BECTS children and 24 healthy children with the same age and sex as the control group.We obtained their magnetic resonance dispersion tensor imaging data by 3.0T MRI.We used AFQ software to extract the main 20 fiber bundles in the brain.All fiber bundles were divided into 100 nodes,FA,MD,AD and RD were extracted from each node.Independent sample t-test and multiple comparison and correction were used to compare the differences of each node.Tested the average FA,MD,AD and RD,and comparing the differences between BECTS group and control group.According to the course of disease,the BECTS group was divided into early group(less than or equal to 3 months)and late group(more than 3 months),comparing the differences between the two groups.Result: A total of 16 main fiber bundles were extracted from the brain.In most of the fiber bundles,the FA of children with BECTS decreased,and the MD and RD increased.The change of AD is not certain,and the hook bundle and The change in the bow beam is most pronounced.Significant differences between the early and late groups have not been found in the disease group.Conclusion: The study suggests that there is a wide range of white matter fiber damage in the brain of BECTS children,and especially in association fiber.The result provides a structural basis for revealing cognitive impairment in children with BECTS.