Non-intrusive methods for probabilistic uncertainty quantification and global sensitivity analysis in nonlinear stochastic phenomena

The objective of this work is to quantify uncertainty and perform global sensitivity analysis for nonlinear models with a moderate or large number of stochastic parameters. We implement non-intrusive methods that do not require modification of the programming code of the underlying deterministic model. To avoid the curse of dimensionality, two methods, namely sampling methods and high dimensional model representation are employed to propagate uncertainty and compute global sensitivity indices.;Variance-based global sensitivity analysis identifies significant and insignificant model parameters. It also provides basis for reducing a model's stochastic dimension by freezing identified insignificant model parameters at their nominal values. The dimension-reduced model can then be analyzed efficiently.;We use uncertainty quantification and global sensitivity analysis in three applications. The first application is to the Rothermel wildland surface fire spread model, which consists of around 80 nonlinear algebraic equations and 24 parameters. We find the reduced models for the selected model outputs and apply efficient sampling methods to quantify the uncertainty. High dimensional model representation is also applied for the Rothermel model for comparison. The second application is to a recently developed biological model that describes inflammatory host response to a bacterial infection. The model involves four nonlinear coupled ordinary differential equations and the dimension of the stochastic space is 16. We compute global sensitivity indices for all parameters and build a dimension-reduced model. The sensitivity results, combined with experiments, can improve the validity of the model. The third application quantifies the uncertainty of weather derivative models and investigates model robustness based on global sensitivity analysis. Three commonly used weather derivative models for the daily average temperature are considered. The one which is least influenced by an increase of parametric uncertainty level is identified as robust.;In summary, the following contributions are made in this dissertation: 1. The optimization of sensitivity derivative enhanced sampling that guarantees variance reduction and improved estimation of stochastic moments. 2. The combination of optimized sensitivity derivative enhanced sampling with randomized quasi-Monte Carlo sampling, and adaptive Monte Carlo sampling, to achieve higher convergence rates. 3. The construction of cut-HDMR component functions based on Gauss quadrature points which results in a more accurate surrogate model, derivation of an integral form of low order partial variances based on cut-HDMR, and efficient computation of global sensitivity analysis based on cut-HDMR. 4. The application of efficient sampling methods, RS-HDMR and cut-HDMR for the quantification of Rothermel's wildland fire surface spread model. 5. The uncertainty quantification and global sensitivity analysis of a newly developed immune response model with parametric uncertainty. 6. The uncertainty quantification of weather derivative models and the analysis of model robustness based on global sensitivity analysis.