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The Use of Attenuated Total Reflectance - Fourier Transform Infrared Spectroscopy to Study The Transduction Dynamics of Lipid Bilayers

Posted on:2014-01-10Degree:Ph.DType:Dissertation
University:University of California, DavisCandidate:Hernandez, Mateo Robert Preeze, IIFull Text:PDF
GTID:1451390005984784Subject:Chemistry
Abstract/Summary:PDF Full Text Request
The use of attenuated total reflectance - Fourier transform infrared spectroscopy (ATR-FTIR) towards investigating model lipid systems is detailed here. These lipid systems vary in mono- to multi- component lipid mixtures. Studies here show that by controlling the components within the lipid mixture one may control the its physical properties when deposited onto different ATR surfaces. Properties such as the resulting aggregate structure, acyl chain ordering within the hydrophobic interior, and relative hydration of the amphiphilic lipid head group. Single and binary component lipid mixtures resulting in aggregate structures of adsorbed 2-D planar lipid monolayers, bilayers, 3-D spheroidal lipid structures. These aggregate structures further extend into lipid and glycolipid environments.
Keywords/Search Tags:Fourier transform infrared spectroscopy, Attenuated total reflectance, Lipid systems, Aggregate structures, Chemistry, Component lipid mixtures
PDF Full Text Request
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