The pharmacokinetics of bromide in cats

The pharmacokinetics of bromide were determined following single dose intravenous and oral administration of sodium bromide to six healthy cats. The influence of repeated treatments on the elimination phase of the pharmacokinetic profile of the drug was evaluated in a different group of cats. The ion selective electrode (ISE) method was used for the determination of serum bromide concentrations. Data were analyzed using a noncompartmental pharmacokinetic model.;A single dose of 64 mg/kg of sodium bromide was administered to six healthy cats as an intravenous bolus. Fourteen weeks to twenty weeks after the intravenous administration, 64 mg/kg was administered orally as a single dose to the same group of cats. The elimination half-life (t;One oral dose of 50 mg/kg of sodium bromide was administered to a second group of cats. The elimination t;Based on a therapeutic serum bromide concentration range of 798 to 1597 ug/mL (10 to 20 mmol/L), an optimum maintenance dose between 7 mg/kg/d and 15 mg/kg/d is recommended for cats.