| Optical coherence tomography is a new imaging technology providing high resolution, cross sectional views of the retina. These images detail microscopic retinal pathology, and are particularly promising for their ability to yield objective, numerical measurements of retinal features in vivo. These measurements may help improve treatment protocols for retinal pathologies involving edema or destruction of tissue layers. However, the measurement repeatability has not been well characterized in the literature. Moreover, there is not a good system available for automatically making thickness measurements from images. Finally, subject motion during scan acquisition causes uncertainty in the precise retinal region imaged. In this dissertation, we address all of these shortcomings, using clinical studies to assess the repeatability and computer vision to present solutions to the other two problems. |
