| The kinetics of iron removal from diferric transferrin by nitrilotris (methylenephosphonic acid) (NTP), N,N-bis(phosphonomethyl)glycine (DPG), N-phosphonomethyliminodiacetic acid (PIDA), nitrilotriacetic acid (NTA), and pyrophosphate (PP;The results have been interpreted in terms of two parallel pathways for iron removal, one that is first-order in ligand and another that is saturable. Phosphonic acids remove iron predominantly by the saturation pathway, while isostructural NTA does so exclusively by the first-order pathway. For PP;The kinetics of iron removal by Pp;Chloride, fluoride, nitrate, thiocyanate, bicarbonate, sulfate, and perchlorate all increase the rate of iron removal by the first-order pathway but have varying effects on the saturation process. Anions virtually eliminate the saturation pathway for NTP and reduce significantly the rate of removal by this pathway for DPG. Conversely, they tend to increase the maximum rate of this pathway for PP... |
