Using chemistry to reveal the consequences of post translational modifications in cancer

Post translational modifications (PTMs), including glycosylation and acetylation, have a wide variety of implications in cells. My goal was to explore the molecular consequences of PTMs using chemical approaches to reveal pathways that are important to human disease, including cancer. This manuscript uncovers a variety of chemical probes that have been used to study mucin O-linked glycosylation, O-GlcNAc modification, and aspirin-dependent acetylation.