One Animal Experiment For Heartech Left Ventricular Partitioning Device In Treatment Of Left Ventricular Aneurysm

Background and Objectives: Left ventricular restoration is one of the treatments for post-MI ventricular aneurysm and dilated cardiomyopathy that can decrease the LV volume and restore the LV geometry,thereby blocking the progress of heart failure.With the development of medical technology,a variety of surgical ventricular restoration and left ventricular restoration devices have been developed,but none has been able to become generalized as a routine treatment.Wherein,percutaneous ventricular restoration is a new treatment for post-MI ventricular aneurysm,in this method we use a catheter to deploy the left ventricular partitioning device(LVPD)at the apex to improve cardiac function by partitioning the non-dynamic chamber of ventricular aneurysm.Parachute LVPD,invented by the Cardiokinetix Company,is the only left ventricular partitioning device so far obtaining CE certification.Its efficacy and safety were preliminarily confirmed by previous clinical trials.According to the characters of Chinese patients,Shanghai Heartech Medical Scientific Company has invented a domestic LVPD(Heartech LVPD).Our study aims to evaluate the effect of Heartech LVPD in an animal model with left ventricular aneurysm.Methods and Results: Four animal models of left ventricular aneurysm were established.The LVPD was implanted 12 weeks after the modeling.The animals were reexamined 16 weeks after the implantation of LVPD,then all the LVPD was removed out and a scanning electron microscope used to evaluate the surface of the LVPD after execution of the animals.Left ventricular pressure and volume were measured at five time points: before modeling,after modeling,before implantation and after the implantation of LVPD and 16 weeks later.Data after the implantation(compared with data before the implantation):(1)Left ventricular end-diastolic volume: 51.60?2.69 ml vs 61.51?4.67 ml,P=0.01;(2)Left ventricular end-systolic volume: 26.95?3.30 ml vs 40.71?4.93 ml,P<0.05;(3)Left ventricular ejection fraction: 47.88%?4.54% vs 33.90%?4.29%,P<0.01;(4)Stroke volume: 24.65?2.15 ml vs 20.79?2.17 ml,P<0.05;(5)Cardiac output: 4.16?0.33L/min vs 3.21?0.36L/min,P<0.01;(6)Mechanical efficiency: 64.73%?4.34% vs 48.88%?5.07%,P<0.01.Data 16 weeks after the implantation(compared with data before the implantation):(1)Left ventricular end-diastolic volume: 51.53?3.33 ml vs 61.51?4.67 ml,P<0.01;(2)Left ventricular end-systolic volume: 25.02?1.81 ml vs 40.71?4.93 ml,P<0.01;(3)Left ventricular ejection fraction: 50.13%?2.99% vs 33.90%?4.29%,P<0.01;(4)Stroke volume: 26.39?2.01 ml vs 20.79?2.17 ml,P<0.01;(5)Cardiac output: 3.54?0.38L/min vs 3.21?0.36L/min,P<0.05;(6)Mechanical efficiency: 67.56%?1.78% vs 48.88%?5.07%,P<0.01;(7)Heart rate: 134.50?15.00/min vs 154.25?8.34/min,P<0.05;(8)All surface of the LVPDs was covered by cardiac endothelium.Conclusion: A significant reduction in LV volume and a corresponding improvement in LV systolic function and mechanical efficiency occurred after LVPD implantation,indicating a beneficial effect of this device in treatment of left ventricular aneurysm.