Superior Scheme Screening Research For External Therapy Of Traditional Chinese Medicine Of Diarrhea-predominant Irritable Bowel Syndrome And Potential Mechanism Of Action Based On Clinical Evidence

Objective: 1.To screen the best external treatment of traditional Chinese medicine for diarrhea irritable bowel syndrome(ibs-d),To provide evidence-based medical evidence for the treatment of ibs-d;2.To select the optimal intervention scheme for external treatment of ibs-d in traditional Chinese medicine to provide reference for clinical decision-making.3.Explore the potential mechanisms of optimal interventions and provide ideas for further research.Methods:1.By using the computer to retrieve Chinese hownet database,Chinese biomedical literature,ten thousand,Pubmed,Embase database,Web of Science and the Cochrane Library,comprehensive retrieve all about diarrhea type irritable bowel syndrome clinical randomized controlled trials,adopt the method of artificial selection to collect evidence of external treatment of traditional Chinese medicine in the treatment of IBS-D,by the two researchers used the Cochrane faced recommended bias Risk assessment tool for Risk of bias,tool of quality evaluation in testing.Net Meta analysis was used,and Win BUGS1.4.3,Stata12.0/SE and R3.4.2 software were used for statistical analysis and drawing.2.The databases of cnki,Chinese biomedical literature,wanfang database,Pubmed,Embase,Web of Science and Cochrane Library were searched by computer,and the clinical randomized controlled trials containing the optimal external treatment of TCM were comprehensively searched.Entropy weight-TOPSIS method and Excel software were used to rank the best clinical intervention plans of TCM external treatment.3.Search Uni Prot database(http://www.uniprot.org),TCMSP database(http:// ibts.hkbu.edu.hk/ LSP/ tcmsp.php),using Maestro software,Discovery studio software,using the same Source modeling,molecular docking techniques,and exploring the potential mechanisms of optimal interventions.Results:1.In terms of improving the total effective rate and improving the IBS-SSS scale of IBS-D patients,the order of moxibustion was the highest,with the probability of 91.7% and 96.8%,respectively;2.The best way to treat IBS-D by moxibustion is to separate the medicine.The specific operation is as follows: Take 2.5g compound powder(Fu Zi,Rou Gui,Mu Xiang,Hong Hua,Dan Shen)and add yellow wine to make a paste.Made into a medicine cake(diameter 2.3cm,thickness 0.5cm),take Tianshu(bilateral),Shangjuxu(bilateral)for the separation of medicine moxibustion,the amount of moxibustion is two strong each hole,once every day,10 times for One course of treatment,each treatment interval is 3 days,a total of 2 courses of treatment.3.Scutellarein and Tournefolic Acid A in the moxibustion moxibustion can act on the serotonin 3 receptor and μ-opioid receptor,inhibit colonic peristalsis,reduce visceral hypersensitivity and regulate brain-intestinal interaction.Conclusion:Current clinical evidence show that moxibustion is likely to be the best of traditional Chinese medicine external treatment,herb-partitioned moxibustion is the best solution,specific operation is as follows: take 2.5g compound powder(Fu Zi,Rou Gui,Mu Xiang,Hong Hua,Dan Shen)and tune into a paste made of yellow rice wine medicine bread(2.3 cm in diameter,the thickness of 0.5 cm),take days to Tian Shu(double side),the Shang Ju Xu (double side)for every drug moxibustion,moxibustion quantity for each hole two strong,tertian,10 times for a period of treatment,the treatment interval between 3,a total of treatment 2 course of treatment.The mechanism of the treatment of IBS-D by moxibustion moxibustion may be related to serotonin 3and ovarian cyanate A in serotonin 3 receptor and μ-opioid receptor,inhibiting colonic peristalsis,reducing visceral hypersensitivity and regulating brain-intestinal interaction.