Engineering 2D Mesoporous Silica@MXene-Integrated 3D-Printing Scaffolds For Combinatory Osteosarcoma Therapy And Bone Regeneration

The rising concerns of the recurrence and bone deficiency in surgical treatment of malignant bone tumor have raised an urgent need of the advance of multifunctional therapeutic platforms for efficient tumor therapy and bone regeneration.Herein,we report on the construction of a multifunctional biomaterial system by the integration of two-dimension（2D）Nb₂C MXene wrapped of S-nitrosothiol（R-SNO）-grafted mesoporous silica with three-dimensional（3D）-printing bioactive glass（BG）scaffolds（MBS）.The near infrared（NIR）-triggered photonic hyperthermia of MXene in NIR-II biowindow and precisely controlled nitric oxide（NO）release are coordinated for multi-target ablation of bone tumor to enhance the localized osteosarcoma treatment in vivo.The in-situ formed phosphorus and calcium components degraded from BG scaffold promote bone-regeneration bioactivity,which is further augmented by sufficient blood supply triggered by on-demand NO release.The tunable NO generation plays a crucial role in sequential adjuvant tumor ablation,combinatory promotion of coupled vascularization and bone regeneration.This study demonstrated a combinatory osteosarcoma ablation and a full osseous regeneration as enabled by the implantation of MBS.The design of multifunctional scaffolds with the specific features of controllable NO release,highly-efficient photothermal conversion and stimulatory bone regeneration provides an intriguing biomaterial platform for the diversified treatment of bone tumors.