Study On Er-Bai Decoction Treat Slow Transit Constipation Mechanism

Objective:First,understanding of the etiology and pathogenesis of slow transit constipation,brain gut interaction mechanism,interacion of 5-HT and gastrointestinal function,psychology and understanding of ancient and modern Traditional Chinese Medicine on constipation etiology,pathogenesis,treatment.Second,Study on Er-bai Decoction treat slow transit constipation mechanism.It provides new treatment ideas and theoretical support the treatment for slow transit constipation.Methods:First,Theoretical research:Collectted relevant literature and ancient books,we systematically reviewed the etiology and pathogenesis of slow transit constipation,brain gut interaction mechanism,interacion of 5-HT and gastrointestinal function,psychology and understanding of ancient and modern Traditional Chinese Medicine on constipation etiology,pathogenesis,treatment.Second,Experimental study:Made slow transit constipation rat model,then the rats were randomly divided into blank control group,model control group,low Er-bai Decoction group,high Er-bai Decoction group,mosapride group,each group was 10 rats.The blank control group were fed normally;the model control group after modeling slow transit constipation does not take any intervention;the low Erbai Decoction group after the success of modeling were taken Erbai Decoction with concentrated to 0.6g/mL;the high Erbai Decoction group after the success of modeling were taken Erbai Decoction with concentrated to 1.8g/mL;the mosapride group modeling after the success of modeling were taken taking 1 mg/ml Mosapride.Observed general condition of the rats(food intake,mental state,skin condition),stools,serum 5-HT,the content of CGRP and Ach activity,visceral sensitivity and TpH1 expression after treatment.Comparedthe different indicators between the groups,we analysised mechanism of Erbai Decoction treat slow transit constipation.Results:First,theoretical study shows slow transit constipation is a multiple factors induced disease.Brain gut interaction is an important mechanism of slow transit constipationand 5-HT is an important neurotransmitter regulation of intestinal function and psychological.The recognize of Traditional Chinese Medicine is the occurrence of constipation is not only related to the spleen and stomach,intestine,but also liver,lung and kidneyare important affecting factors.Thetreatment of slow transit constipation patients shoulde take into account other organs.Second,experimental study shows Er-bai decoction can improve TpH1 expression and promote serum 5-HT and colon tissue CGRP synthesis,enhance AchE activity and visceral sensitivity to improve slow transit constipation rat constipation symptoms.Conclusion:Erbai decoction can promote synthesis of 5-HT and CGRP,and improve the ache enzyme activity and intestinal motor and secretory function,to play the role on treatment of slow transit constipation.