| Purpose : The epidemiological characteristics of influenza in children in Shenyang Children’s Hospital were analyzed to provide a basis for the prevention and control of influenza virus in Shenyang.The multivariate statistical analysis method was used to analyze the TCM symptom type of childhood influenza,explore the combination law of its symptoms,and analyze the characteristics of TCM syndrome of pediatric influenza.The clinical efficacy of biliary extract syrup in the treatment of influenza-like cases was evaluated.Material and method:1.A total of 3577 children with acute respiratory infections who were hospitalized in the internal medicine ward of Shenyang Children’s Hospital from December 2021 to November2022 were selected,and after admission,multiple RT-PCR methods were used to improve the etiological detection,and the pathogen detection was divided into influenza-positive group and virus-negative group according to the pathogen detection results,and the epidemiological characteristics of influenza were analyzed.2.A total of 542 children with influenza who were hospitalized in the internal medicine ward of Shenyang Children’s Hospital from December 2021 to November 2022 were selected,a influenza TCM syndromes observation table was formulated,the general data and four diagnosis information of the children were collected,and the distribution law of TCM symptom types was analyzed and summarized by multivariate statistical analysis method.3.A total of 80 children with Influenza-like illness who attended the emergency department of Shenyang Children’s Hospital from December 2021 to November 2022 were randomly divided into two groups,with 40 cases in each group,the experimental group was given oral Danmu extract syrup and the control group was given oseltamivir orally for 5 days,and the clinical efficacy difference between the two groups was compared.Results:1.Analysis of epidemiological characteristics of influenza in children:(1)Among the 3577 children,802 cases of influenza virus were positive,with a positive rate of 22.42%,including199 cases of influenza A,578 cases of influenza B,and the positive rate of influenza virus appeared in 2 peaks within one year,distributed in December and August,the positive rate was 39.83% and 33.79%,and the positive rate of winter,spring,summer and autumn was34.32%,1.39% and 24.79%,1.93%;(2)Among influenza-positive children,the school-age positive rate of influenza A is lower than that of influenza B,and the positive rate of early childhood is higher than that of influenza B;(3)The incidence of influenza A convulsions was higher than that in influenza B group,and the incidence of vomiting and diarrhea symptoms in influenza A group was lower than that in influenza B group.The fever peak and fever days in the influenza-positive group were higher than those in the virus-negative group,and the proportion of fever,cough,sore throat,headache,vomiting,diarrhea and convulsive attacks in the influenza-positive group was higher than that in the virus-negative group;(4)Compared with the influenza-positive group and the virus-negative group,the incidence of acute bronchitis was higher than that of the virus-negative group,and the incidence of acute upper respiratory tract infection,neonatal pneumonia and severe pneumonia was lower than that of the virus-negative group,and there was no significant difference in acute bronchial pneumonia.Among influenza-positive children,the incidence of neutropenia was the highest,followed by febrile seizures,abnormal myocardial enzyme profile,liver function damage,gastroenteritis,benign myositis,otitis media,the incidence of otitis media,febrile seizures,benign myositis,neutropenia and gastroenteritis in influenza-positive children was higher than that in the virus-negative group,the incidence of febrile seizures in influenza A group was higher than that in influenza B group,and the incidence of benign myositis,neutropenia and gastroenteritis was lower than that in influenza B group.2.The second part of the study shows that a total of 16 common factors were extracted from factor analysis,and combined with professional knowledge and expert group opinions,the evidence-symptomatic relationship obtained was used to diagnose the original case.The results showed that wind-heat syndrome was the primary syndrome type,accounting for57.93%,followed by dampwarm disease with syndrome of dampness inhibiting defense qi(12.92%),the syndrome of heat-toxin attacking lung(12.18%),the syndrome of toxic heat obstructing lung(7.93%),the syndrome of wind-cold(6.83%)and the syndrome of external cold and internal heat(2.21%).3.The results of the third part of the study showed that the fever relief time of the experimental group(26.50±8.49)h was significantly lower than that of the control group(37.21±11.79)h,by the survival analysis Logrank test,and the relief time of sore throat in the experimental group(35.67±1.66)h was lower than that of the control group(54.05±1.77)h,and there was no significant difference in the relief time of other symptoms including cough,headache,muscle soreness,nasal congestion and chills(P > 0.05).Conclusion:1.The epidemic of influenza in children has obvious seasonal distribution characteristics,with influenza B virus as the main in winter 2021 and influenza A virus in summer 2022,and IVA and IVB can alternately become the dominant strains,and the prevention and treatment of summer influenza cannot be ignored;Influenza A is more likely to be associated with febrile seizures,and influenza B is more likely to be associated with benign myositis,acute gastroenteritis,and neutropenia,and attention should be paid to the prevention and treatment of influenza complications in children.2.Through cluster analysis and factor analysis,it was statistically shown that TCM evidence of children’s influenza was mainly wind-heat syndrome,followed by dampwarm disease with syndrome of dampness inhibiting defense qi,heat-toxin attacking lung syndrome,toxic-heat obstructing lung syndrome,wind-cold syndrome,external cold and internal heat syndrome.3.The clinical efficacy of Danmu extract syrup in the treatment of influenza in children is the same as that of oseltamivir,but the time to relieve fever and sore throat is significantly lower than that of oseltamivir,so children with flu-like illness in children who are wind-heat invading syndrome can be intervened with Danmu extract syrup. |
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