Clinical Study Of Magnetic Bead Pressing On Auricular Acupoints Combined With 0.01% Atropine Eye Drops For Myopia Prevention And Control In Children

Part Ⅰ Questionnaire survey and related factors analysis of myopia in childrenObjective To analyze the disease status and related influencing factors of all myopia children in this study,so as to provide basis for strengthening clinical myopia prevention and control.Method A cross-sectional study was conducted to conduct a questionnaire survey on 160 myopia children and their guardians in this clinical study from October 2022 to August 2023,and visual acuity examination and mydriatic retinoscopy examination were performed on the myopia children.The data obtained were analyzed using SPSS 22.0 software,the counting data was expressed as n(%),and χ2 test was adopted.Pindicated that the difference was statistically significant.Result Among the myopic children surveyed in this questionnaire,there were 124 children with low myopia,33 children with moderate myopia and 3 children with high myopia.①Among children with myopia in different ages,older children were more inclined to moderate and high myopia,while younger children were more inclined to low myopia(P<0.05).②The proportion of children with higher annual height increase was higher(P<0.05).③Children whose parents are nearsighted spend more time reading and writing in preschool.Children whose parents were nearsighted also spent significantly less time outdoors(P<0.05).④ Children with higher degree of myopia spent more time reading and writing outside class,more time on electronic products,more time on reading and writing in preschool,and less time on outdoor activities(P<0.05).⑤Girls spend more time reading and writing after class than boys;Male students spent more time on electronic products than female students,but also spent more time on outdoor activities(P<0.05).⑥ The older the myopia children use electronic products longer;The younger the myopic children,the longer they read and write in preschool(P<0.05).Conclusion The questionnaire survey of myopic children in this clinical study found that age played a role in the occurrence and development of myopic disease.Parents’ myopia and their eye habits and lifestyle may affect the progression of myopia in offspring.Extracurricular reading and writing time,electronic products time,preschool reading and writing time,outdoor activities will also affect the speed of myopia progression.It is suggested that the health Commission,schools,hospitals and parents should take joint action and pay attention to the publicity and education of myopia prevention from the early school age.Part Ⅱ Clinical study of magnetic bead pressing on auricular acupoints combined with 0.01%atropine eye drops for myopia prevention and control in childrenObjective To compare the effect of myopia prevention and control between children treated with magnetic bead pressing on auricular acupoints combined with 0.01%atropine eye drops,those treated with magnetic bead pressing on auricular acupoints alone and 0.01%atropine eye drops alone.Method This is a single-center,prospective,randomized,parallel controlled clinical study on magnetic bead pressing on auricular acupoints combined with 0.01%atropine eye drops prevention and control of myopia progression in children.Auricular point sticking doctor did not set blind.The efficacy evaluation and statistical analysis were blind.In this study,the children with myopia were randomly assigned 1:1:1:1 according to the random number table method.The control group was corrected by frame glasses(F),the test group was divided into three groups:frame glasses+0.01%atropine eye drops group(F+0.01A),frame glasses+auricular acupoints(F+ACU),frame glasses+0.01%atropine eye drops+auricular acupoints group(F+0.01A+ACU).At the time of enrollment,3 months and 6 months,the four groups of myopia children were examined by the nearest naked eye far-vision,mydriatic retinoscopy,computer optometry,corneal curvature,axis length of eye,anterior chamber depth,intraocular pressure,choroidal thickness measured by OCT.All data were analyzed by SPSS 17.0(SPSS Inc.,Chicago,IL,USA)statistical software.Result 182 in total children were included in our study,18 cases were shed,4 cases were eliminated,and a total of 160 children with myopia were finally included.There were 40 cases in the control group and 40 cases in each of the three experimental groups,a total of 120 cases.There were no differences in age and sex among all participants at enrollment(P>0.05).Naked eye vision,diopter,axis length of eye,intraocular pressure,corneal curvature were not different between groups(P>0.05).①Changes in naked eye vision:from enrollment to 6 months,the naked eye vision of the F group(-0.26±0.21)declined the fastest,followed by the F+0.01A group(0.09±0.29)and the F+ACU+0.01 A group(-0.08±0.20),and the F+ACU group(0.07±0.28)declined the slowest.②Changes in spherical equivalent(myopia):from enrollment to 6 months,the myopia diopter of the F group(-0.66±0.34D)increased the fastest,followed by the F+ACU group(-0.32±0.40 D)and the F+0.01A group(-0.29±0.29 D),and the increase of F+ACU+0.01A group(-0.26±0.39 D)was the least(P<0.05).Although the effect of F+ACU group on delaying myopia progression was slightly lower than that of F+0.01A group and F+ACU+0.01A group,the difference was not statistically significant(P>0.05).③Changes in cylinder(astigmatism):from enrollment to 6 months,the cylinder of F group,F+ACU group,F+0.01 A group and F+ACU+0.01A group decreased by-0.26 ±0.23D,-0.22±0.25D,-0.21 ±0.27D and-0.19±0.28D,but there was no significant difference between the control group and the experimental group.(P>0.05).However,it can be seen from the trend of astigmatism that the increase of astigmatism in F group,F+ACU group,F+0.01A group and F+ACU+0.01A group decreased successively.④Changes in axis length of eye:from enrollment to 6 months,the axis length of eye of F group,F+ACU group,F+0.01A group and F+ACU+0.01A group increased by 0.36±0.25mm、0.18±0.14 mm、0.16±0.23 D、0.12±0.11 mm,and the difference between the experimental group and the control group was statistically significant(P<0.05).There was no difference between F+0.01 A group and F+ACU+0.01A group(P>0.05).However,the axial growth of the eyes in both groups was slower than that in the F+ACU group,and the difference was statistically significant(P<0.05).⑤Changes in anterior chamber depth:from enrollment to 6 months,the anterior chamber depth of F group decreased by 0.035±0.08mm,and that of F+ACU group,F+0.01A group,F+ACU+0.01A group increased by 0.044±0.13mm,0.022±0.08 mm,0.058±0.08 mm,and the difference between the experimental group and the control group,was statistically significant(P<0.05).The anterior chamber depth increased the most in F+ACU+0.01A group,followed by F+ACU group and F+0.01 A group,and the three experimental groups increased the anterior chamber depth more than the control group(group F)(P<0.05).⑥Changes in intraocular pressure:from enrollment to 6 months,in the F group,F+ACU group,F+0.01A group,F+ACU+0.01A group,the IOP decreased by 0.46±4.01mmHg,1.56±2.27mmHg,1.73±2.91mmHg,1.90±3.38 mmHg,respectively,and there was a difference between the experimental group and the control group(P<0.05).⑦Changes in choroidal thickness:from enrollment to 6 months,the choroidal thickness of F group,F+ACU group,F+0.01A group,F+ACU+0.01A group,increased by 6.35±27.63μm,23.35±24.12μm,41.85±25.63μm,43.6±27.05μm,respectively,and there were differences between experimental groups and control groups(P<0.05).Compared with the F group,the choroid thickness of the F+ACU+0.01A group,F+0.01A group,F+ACU group was significantly increased(P<0.05).The choroid thickness of the F+ACU+0.01A group was increased than that of the F+ACU group,but there was no difference in choroid thickness compared with the F+0.01A group(P>0.05).⑧Changes in corneal curvature:from enrollment to 6 months,there was no significant difference in horizontal and vertical corneal curvature between control group and experimental group(P>0.05).Conclusion In this study,it indicated that during the progression of myopia,the F+ACU had better naked eye vision than the control group and other experimental groups.It was suggested that auricular acupoints were beneficial to delay the deepening of myopia diopter.It suggested that the experimental group may had a certain effect of delaying the growth of astigmatism.It showed that 0.01%atropine eye drops is better than auricular acupoints in controlling the growth of ocular axis.It indicated that the effect of delaying myopia progression in experimental group was better than that in control group,and auricular acupoints increased more in the anterior chamber depth than 0.01%atropine eye drops,which may be related to the effect of neural regulation of auricular acupoints on the relaxation of regulation and the flattening of lens,thus causing the increase of anterior chamber depth.These effects are better than the effect of 0.01%atropine eye drops on the relaxation of ciliary muscle and the flattening of lens,causing the increase of anterior chamber depth.Moreover,auricular acupoints combined with 0.01%atropine eye drops can synergistic effect of increasing anterior chamber depth.The deepening of the anterior chamber can delay the progression of myopia.It showed that auricular acupoints combined with 0.01%atropine eye drops can coordinate the effect of decreasing IOP.It indicated that auricular point stimulation may lead to choroidal thickness increase through increasing choroidal blood flow density,and may be a secondary effect,but 0.01%atropine caused by choroidal thickness increase may be the main reason.It was found that myopia children treated with magnetic bead pressing on auricular acupoints combined with 0.01%atropine eye drops had better naked eye vision,less myopia diopter progression,more IOP reduction,more anterior chamber deepening,less axial growth,and more choroidal thickness increase.These results indicated that auricular acupoints combined with 0.01%atropine eye drops is more effective in controlling myopia.