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Chiral Separations Of Selected Pharmaceuticals On Brush-Type Chiral Stationary Phases

Posted on:2004-07-10Degree:MasterType:Thesis
Country:ChinaCandidate:Y M LiangFull Text:PDF
GTID:2121360095953187Subject:Chemical Engineering
Abstract/Summary:PDF Full Text Request
Four NASIDs, three -blockers, four respiration-drugs, a chiral reagent and eleven other Pharmaceuticals with representative molecular structures have been selected and tested on chiral Stationary Phase including Whelk-O1, SH-1 , DNB-PG and DNB-Leucine by HPLC in different mobile phases. Based on the results above, the chiral recognition mechanism have been discussed further.It shows that the Whelk-Ol can resolute proglumide, acctyl-tryptophane and procaterol enantiomers while the SH-1 CSP can only resolute the procaterol enantiomers. The -group in this CSP is assumed to be responsible for it since it is not designed to resolute the drugs. Comparing with the structure of Whelk-O1, a acid- -group have been introduced to SH-1 CSP to enhance its chiral recognition ability. The new Whelk-O1-like CSP is assumed to have similar chiral recognition ability with it.The procaterol enantiomers can be resoluted on four CSPs with satisfactory chiral-resolution-factors and the effects of content of polar modifier in mobile phase have been tested. The results show that the chiral-resolution-actors on Whelk-Ol, DNB-PG CSP and DNB-Leucine CSP will increase with the decrease of polar modifier while chiral-resolution-actors almost keep steady on SH-1 CSP.The special -group in procaterol, which can take part in - interaction with both -acid group and -basic group, is the main reason for the broad resolutions and the good space-structure do a good favor. Following the Reciprocal Principle, a procateroal-like CSP has been designed, with the special group the enhanced space structure. The new CSP is expected to get a wide and good chiral recognition ability.
Keywords/Search Tags:Pharmaceutical analysis, HPLC, Chiral recognition mechanism, Chiral stationary phase, Enatiomer separation
PDF Full Text Request
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