Preparation Of Targeted Drug Delivery Material And Microspheres

Targeted Drug Delivery Systems (TDDS) have been an important developing drug field, so it is necessary to develop the research of drug carrier and material. Only the proper proportion of drug carrier or material to drug is the base of satisfied Targeted Drug Delivery Systems. Therefore it is important for the development of new drugs to keen on the research of new drug vector and material revolved. In this paper, PEGCH2COH was prepared and then was deoxidize to PEGCH2CH2NH2. In addition, folate was used to modify chitosan so chitosan-folate was obtained as an targeted delivery material. And then inverse crosslinking-emulsion was used and the chitosan microspheres, PEGlated chitosan microspheres, chitosn-folate microspheres and PEGlated chitosn-folate microspheres were obtained. The major contents include: 1. First, in this paper, PEG was modified to converse one hydroxy end group into a aldehyde group and then using reducer to revert it into amidocyanogen group under the condition of alkalescence. The reactive conditions were also discussed and PEG-COH was charactered by FT-IR.2. Chitosan molecules were modified by introducing folate molecules through chemical reaction, and the reactive conditions that affects the reaction between chitosan and folate were studied. Chitosan-folate was charactered by FT-IR. 3. Since chitosan is a macromolecule, and has a lot of amido groups on the melecules. The chitosan microspheres were prepared using glutaraldehyde as a crosslinking agent and acetylamino benzoate as organic diffusion media respectively. The reactive conditions were also explored and the best condition was found according to the experiments. Then structure and appearance of the microspheres were charactered by IR, SEM and microscope. The results showed that the good size-distributed microspheres could be obtained under the experimental conditions. 4. Chitosan－folate(CSF) was made into microspheres by inverse emulsion using glutaraldehyde as a crosslinking agent and acetylamino benzoate as organic diffusion media respectively. Then the microspheres were charactered by IR, SEM and microscope. The results showed that the chitosan modified by folate microspheres can also be obtained 5. The PEGlated chitosan and PEGlated chitosan-folate microspheres were prepared and charactered by IR, SEM and microscope. The results show that the PEGlated chitosan and PEGlated chitosan-folate microspheres can be prepared by inverse crosslinking -emulsion.