Effects Of Alternative Puffing Regimens On BaP Deliveries In Mainstream Smoke And Correl Ation Between BaP Deliveries And Mutagenicity Of TPM

Tar, nicotine and CO is used generally as the index to evaluate the security of cigarette in the present world. Tar, contain BaP considered the main carcinogen, is the most important index. Based on the study of the deliveries of BaP and other harmful component in mainstream under alternative puffing regimens, the effects on the harmful component deliveries were discussed. Based on the difference of the yield of BaP and the mutagenicity of TPM in different type cigarettes and brands, the correlation between the cigarette types graded in different tar yield and the security of cigarette , and between the yield of BaP and the mutagenicity of TPM were studied. The flowing main conclusion is:The deliveries of harmful components in mainstream smoke vary greatly with the alternative puffing regimens, in some puffing regimens , the yield of BaP and other harmful components deliveried by a low tar light cigarette equal to or even exceed obviously that of a high tar flue-cured cigarette.Based on the difference of the effect on the yield of different harmful components in every puffing smoke with the changes of one puffing regimen, it was concluded the complexity of the effect of alterative puffing regimens on the yield of different harmful components.Decreasing butt length, increasing puffing volume, and shortening puffing alternation all can increase the yield of BaP and other harmful components in mainstream smoke, but the correlation is not linear. The results show that the effect of changing a certain smoking condition on deliveries of nicotine is much great than that of BaP, but the conclusion will be reverse if two or three puffing regimens increasing the yield of harmful component are used in the mean time.The yield of BaP of low tar light cigarettes is lower than that of high tar flue-cured cigarettes. The yield of BaP have no correlation with tar , nicotine ,CO in mainstream smoke and the grade of the cigarettes ,and the same as the mutagenicity of TPM with the yield of BaP, tar , nicotine ,CO in main stream smoke and the type and the grade of the cigarettes. The results show that the TPM of the choosen cigarettes can induce mutagenesis of chromosome of mouse marrow cell, and the difference of mutagenicity is highly significant among the brand cigarettes.