Study On Synthesis And Anion Recognition Of The Fluorescence Receptors Containing Anthracene

Recently, considerable attention has been focused on the design of receptors that have the ability to selectively bind and sense anions due to their playing an important role in biology, medicine and environment science. By far, the basic strategy for the construction of anion-binding receptors is to exploit electrostatic interaction and/or hydrogen bonds, or lewis acidic metal-ligand interactions.Functional moieties such as urea, thiourea, and amide that can form relatively strong hydrogen complexes with anionic species and rely less on pH values have been extensive exploit in the design and synthesis of anion receptors. Many fluorescent chemosensors follow the approach of the covalent attachment of signaling subunits and binding sites, the coordination site binds the anion with high selectivity and the signaling subunits is to act as a signal transducer with sensitive optical response. These sensors are significant towards anion-recognition-based real-time assay of environmental anionic contaminations, clinical diagnoses of deleterious anions and microanalysis.In this thesis, a series of anion receptors bearing anthracene fluorophore were synthesized and their binding properities with a variety of anions were studied. The main contents are as follows:1. The Binding Sites of Receptors and the Fluorescent Chemosensor for AnionsIn this chapter, receptors bearing various anion binding sites and chemosensors containing different fluorophores were reviewed. Their ability to selectively bind and sense anions were detailed presented.2. Study on Synthesis and Anion Recognition of the Fluorescence Receptor Containing Amide GroupA novel anion receptor bearing anthracene fluorophore and acyl-hydrazine was synthesized and identified by 1H NMR, MS, IR and elemental analysis. Theinteraction between the receptor and various anions( AcO , H2PO4 , Cl , Br and I- ) was studied by fluorescence spectrum. The results demonstrate that receptor II had an excellent selective recognition for AcO-. Receptor II binds anions with a selectivity in the order of AcO->H2PO4-> >C1-, Br- and I-. The obtained fluorescence data indicate that 1:1 stoichiometry complex is formed between receptor II with AcO- and H2P