Study On The Synthesis And Surface Activity Of PAMAM Dendrimer

Dendrimers,which have hyperbranched, well defined and monodisperse structures, can be formed by reiterative reaction sequences starting from smaller molecules named " initiator core " . And its molecular weight, size, shape and functional group over surface can be controlled by the reactions and synthetic building blocks used. Great attention has been paid to dendrimers in many fields, such as DNA delivery, catalyzer, Molecular Self-Assembly, et al. The synthesis of PAMAM dendrimers involved in genernal method cost so much time that its research is limited in lab. So the optimized synthesis conditions of 0.5 and 1.0 G (generation) PAMAM are studied in this paper, and the apt conditions which can shorten reaction time greatly are presented. 1.5~3.0 G PAMAM were synthesized as described elsewhere. And the method of products purification was advanced. IR, 1H-NMR, 13C-NMR, Elemental Analysisd and potentiometric titration are taken to character the products. Especially, the characterization with 13C-NMR is a feather of this thesis.Finally, the surface activity of 0.5~3.0G PAMAM is studied with Wilhelmy measure plate method. It is found that the half generation PAMAM dendrimers, which are expected to be a kind of novel Surfacant, have fine surface activity. The integrated generation PAMAM dendrimers also have some surface activity. And interestingly, other then rise in turn, the 2.0G PAMAM dendrimers' surface activity is higher than 1.0 and 3.0G PAMAM dendrimers.