Study Of Supramolecular Inclusion Complexes Of β-cyclodextrin And Its Derivatives

Supramolecular inclusion complexes of cyclodextrin were introduced briefly. This paper consists of five chapters.Chapter 1: The main property of cyclodextrin and surfactants were summarized. At the same time, the actual state of study on supramolecular inclusion complexes of cyclodextrin and the recent development have been reviewed.Chapter 2: The interaction ofβ-CD with Triton X-100 was studied by surface tension, fluorescence and ¹H NMR measurements. The experimental results indicate that Triton X-100 fails to form micelles in aqueous solution in the presence of excessβ-CD. The hydrophobic moiety of Triton X-100 was incorporated into the cavity ofβ-CD andβ-CD screens the built-in phenyl ring of Triton X-100 from iodide ions. ¹H NMR spectra provide additional evidence for such supramolecular inclusion complex with stoichiometry of 1:1. Apparent formation constant was estimated to be 3.04×10⁴ mol·L^-1. A special configuration of the complex has been proposed based on experimental results and molecular dimensions.Chapter 3: Inclusion ofβ-CD with PL was studied by surface tension, cloud point, color reaction and ¹H NMR measurements. It was established that inclusion ofβ-CD with PL affords supramolecular complexes with the stoichiometry of 2:1 and 3:1 in aqueous solution. Inclusion complex with the stoichiometry of 2:1 arises from the incorporation of lauryl group of PL into the cavity ofβ-CD, whereas inclusion complex with the stoichiometry of 3:1 arises from the incorporation of polyoxyethylene group of PL into the cavity ofβ-CD. A special configuration of the complex has been proposed based on experimental results and molecular sizes.Chapter 4: The fluorescence spectra of ANS in various solvents and cyclodextrins were studied in detail. It was obviously shown that the ANS emitted dual fluorescence. The effects of solvents polar and hydrogen bonds to fluorescence properties of ANS had been studied in different solvents. It was found that fluorescence intensity of ANS can be enhanced inβ-cyclodextrin and its derivatives. The stoichiometry of supramolecular complexes formed is 1:1 forβ-cyclodextrin and its derivatives with ANS. The results suggest that the substituent on the cyclodextrin derivatives changes its original binding ability. At the same time, the influorescence and mechamism of pH and surfactant to the system of ANS/CDs were discussed.Chapter 5: Supramolecular inclusion complexes ofβ-CD and its derivatives with TNS were discussed in this paper. It was found that fluorescence intensity of TNS can be enhanced inβ-cyclodextrin and its derivatives. The results suggest that inclusion ofβ-CD and its derivatives with TNS affords supramolecular complexes with the stoichiometry of 1:1 in aqueous solution. The complex stability is dominated by Van der Walls and hydrophobic interactions between host and guest. At the same time, the influorescence of surfactant to the system of TNS/CDs was discussed.