Studies On The Synthesis, Characterization And Biological Activities Of Triazole Compo Unds Containing Triazole Or Thiadiazole

As an important type of fungicides, triazole compounds are highly efficient, broad spectrum and inward-absorbent. In this paper, we have reviewed the recent advances in the studies on the structures, synthesis, action mechanism, structure-activity relationship and biological activities of triazoles, different active groups of action mechanism were inducted into the triazole compounds according to the concept of bioisosterism. Triazole and thiadiazole were introduced into the structures of triazoles compounds and twenty novel triazole compounds were synthesized in two types.Thirteen triazole compounds have been synthesized by synthesized 2-(lH-l,2,4 traziol) acetylhydrazine, phenyl isothiocyanate and then characterized by elemental analysis, IR spectra and ~1H NMR spactra. There single crystals of four compounds have been obtained successfully and characterized by single crystal X-ray diffraction analysis. Base of these, the properties of physical chemical and spectroscopy of these compounds are systematically investigated. The reaction methods and reaction conditions have been compared, investigated and analysized. The results of bioassay indicate that most of these compounds have some biological activities. The biological activitie is improved when two p-hydrogen atoms on the benzene ring are substitued by chlorine atoms.Seven compounds of thiadrazole derivative are synthesized by 2-(1H-1,2,4 traziol) acetylhydrazine, carbon disulfide, bromo(chlorine)-aoetophnone, and characteried by IR, ~1H NMR, MS, EA. The properties of physical chemical ,spectroscopy, the reaction methods and reaction conditions of these compounds are systematically investigated...