The Suzuki Reaction Of Arylsulfonyl Chlorides And Arylboronic Acids Catalyzed By A Recyclable Polystyrene-supported NHC-Pd Complex

The synthesis of unsymmetrical biaryls plays a crucial role in organic synthesis mainly because of their numerous applications in pharmaceuticals, polymers, advanced materials and liquid crystals. The Suzuki cross-coupling reaction which produces biaryls has proven to be one of the most versatile methods, although several other methods are available for this purpose. The key advantages of the Suzuki coupling are the mild reaction conditions and the commercial availability of the diverse boronic acids that are environmentally safer than other organometallic reagents. The scope of Suzuki reaction has been extensively studied for aryl bromide and iodide substrates, and the cross-couplings of aryl chloride substrates received considerable attention in view of their attractive cost and readily available diversity. However, the use of aryl chlorides as substrate has proven difficult because of their inactivity.Arylsulfonyl chlorides are inexpensive and readily available compounds, and are more reactive than the corresponding aryl chlorides. Therefore, they can be used as reactants in place of the corresponding aryl chlorides in some cases.Heterogeneous catalysts have many advantages for industrial applications. The NHC ligands bind to both Pd0 and PdII centers substantially stronger than those...