Studies On The Fluorescence Properties Of Intra-molecular Charge Transfer Compounds, Amino Acid Imide Derivates And Their Interactions With Cucurbiturils

1. Synthesis the Intra-molecular Charge Transfer Compounds and Fluorescence properties studies and on the interaction of Cucurbit[n=6]urils with themThe molecular structures, configurations and the environmental effects on the fluorescence emission of organic compounds are tremendous important. The researches in this field will be benefit the design and synthesis of compounds with high fluorescence quantum yield. In this paper, a series of intra-molecular charge transfer compounds named L1 -L3 have been designed and synthesized and the structures are characterized with ¹H NMR.A set of fluorescence spectra has been measured for these compounds as the guests and cucurbit[n=6]urils as the host. At a room temperature, the binding constants (K) of L1(NO₃^-) for STMQ[6] in water and Na₂SO₄ aqueous are 83 ± 10M^-1 and 31 ± 5M^-1, repestively. Of L2(NO₃^-) for STMQ[6] in water is 38± 8 M^-1 and L2(I^-) is 49 ± 12M^-1. And interaction pattern of inclusion complexes of cucurbit[n=6]uril(host) and L1(guest) has been monitored and deduced by ¹H NMR.2. Synthesis of P(a)-Amino acid imide derivates and Fluorescence properties studies on the interaction of Cucurbit[n=6,7]urils with themP-amino acids and their derivatives are important components of many natural products. They are the precursors for the synthesis of p-peptides and antibiotics with β-lactam structure, which are widely used in the field of pharmaceuticals and biochemistry.In this thesis, four β(α)-Amino acid derivates are designed, synthesized and characterized according to the knowledge that the small organic molecular with phenyl or pyridine is easy to interact with cucurbit[n]uril. Molecular recognitions of β(α)-amino acid derivates hydrochlorides (guest) by cucurbit[n=6,7]uril have been studied by fluorescence spectra. The results indicated that the fluorescence intensities of a-Amino acid derivates are rarely changed wherease the fluorescence intensities of β-Amino acid derivates are quenched.