Fabrication Of MoO₃ Nanofibers And Drug Loading PVA Nanofibers By Electrospinning

Polyvinyl alcohol (PVA/)ammonium molybdate composite fibers were prepared by using sol–gel processing and electrospinning technique. After calcinations of the above precursor fibers at 500°C, MoO3 nanofibers with a diameter of 100–150nm were successfully obtained. The procucts were homogeneous diameters of 50-150nm and uniform morphology with smooth surface. MoO3 nanoplatelets and submicron platelets were prepared by further calcinations of the MoO3 nanofibers at 600°C and 700°C. The products were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT–IR) and scanning electron microscopy (SEM). A possible growth mechanism for the MoO3 nanofibers and nanoplatelets was suggested.Electrospinning was applied to the preparation of drug loading biocompatible polyvinylalcohol (PVA)/benzoic acid nanofibers with water as solvent for potential use in skin-relatedtherapy. The collected electrospun nanofibers mats were shown to release the drugs at various rates and profiles based on the drug content. At the initial stage, benzoic acid was rapidly released from the nanofibers as a linear function of the time square root. The specific aim ofthis study was to assess whether this system might be of interest as a controlled materials for skin drug basing on its porosity which benefits skin breathing and prevents bacteria from entrancing and basing on its high surface area and high porosity which benefits drug absorption.Electrospinning was applied to the preparation of drug-laden biocompatible polyvinylalcohol (PVA)/ciprofloxacin nanofibers with water as solvent for potential use in topical drug administration and wound healing. At the initial stage, ciprofloxacin was released from the nanofibers as a linear function of the time. The specific aim of this study was to assess whether this system might be of interest as a green delivery system for skin and wound-related therapy basing on its porosity which benefits skin breathing and prevents bacteria from entrancing.