Studies On The Synthesis Of Pyrrolidin-2-one Derivatives

β-dicarbonyl compounds are a variety of active methylene compounds, which have proven to be very useful in organic synthesis. Under alkaline catalyst , active methylene compounds were changed into carbanions, the carbanions make nucleophilic reagent to take place many chemical reaction. most typical examples is nucleophilic substitution reaction that is together with halogenated hydrocarbons.In our research on study chemical reaction of active methylene compounds and brom(o)-acetophenone. Because of brom(o)-acetophenone is compound that contain carbonyl and halogen ,which will take place electrophilic substitution and nucleophilic addition. When active methylene compounds are ethyl acetoacetate andβ-diketone, controlling reaction condition, we have found that mono-substitution's production and di-substitution's. production is isolated; active methylene compounds are acetoacetanilide and acetoacetanilide derivate, pyrrolidin-2-one derivants were obtained by substitution and close-ring reaction .but there is no report about it.In this paper, Fourteen new compounds were synthetized and characterized via 1HNMR, 13CNMR and IR.