The Co-enzyme Model NADH HANTZSCH Oxidation And Application In Organic Chemistry

The co-enzyme NADH have an important impacts of the redox reaction in biological system. But BNAH, HEH and AcrH₂ have been used in organic synthesis. The co-enzyme NADH model compounds reaction has been focused on the mechanism of H^- transferation, asymmetrical reduced reaction, NADH model compounds's oxidation and the investigation of the new reaction etc.The paper will introduce the progress of hantzsch ester in organic chemistry and the studies on catalytic aerobic oxidation.First of all, We have synthesize a serial of hantzsch compounds and choosed a lot of catalyst which would be used to try to catalytic aerobic oxidation of hantzsch compounds to the correspondence compounds. To gain a good effect, We have attempted to select suitable solvent and temperature for the reaction. Finally, We found that cupric chloride dihydrate was fit for oxidation of hantzsch compounds and had a good yield. Most of all hantzsch compounds were smoothly oxidized to the correspondence compounds and have yields of 89%-98% . But the strong electron-withdrawing substituent nitro substituent remarkably retarded the reaction, electron-donating substituent did not remarkably effect the reaction.Completed to catalytic aerobic oxidation of hantzsch compounds. Have selected different of solvent and temperature, We have attempted to utilize cupric chloride dihydrate to catalytic aerobic oxidation of 1,3,5-trisubstituted pyrazolines to he correspondence compounds. All compounds have a good yield exceed 90%.