Study On Synthesis Of Trazodone And 2-(2-Hydroxy-5-methacrylyloxyethylphenyl)-2H-benzotriazole

As the people living pace becomes fast, people are having more mental stress. Depression has become common disease. In the last few decades, people have made great progress in the research of antidepressant drug. Trazodone is the second generation of antidepressant drug, it has applied as anti-anxity for many years in clinical. Trazodone as an anti-anxiety and antidepressant drug, it is pronounced on antidepressant and sedative. At the present, the technological level of Trazodone synthesis is backward. In this paper, using 2-chloropyridine, hydrazine hydrate and chloroaniline as raw materials, it has proposed a suitable way for industrial production Trazodone Hydrochloride, focused on the preparation of various programmers and intermediate purification technology optimization.The main work is as follows:1: A variety of methods of synthesizing 1,2,4 triazolam [4,3-a] pyridine -3 (2 H) have tried and optimized, it has finally made up a excellent yield.2. For the preparation of 1 - (3 - chlorophenyl) piperazine hydrochloride . we have adopted a new synthetic programmers, which changed the purification process and achieved good results. The product yield improve from 50 percent to 89 percent.3: Making improvement in refining 4 - (3 - chlorophenyl) -1 - (3 - chloropropyl) -piperazine hydrochloride .we have used way of using excessive 1 - chlorine -3 -bromopropane . Making improvement in purification process, which achieved good results. The product yield improve from 45 percent to 95 percent.4: We have adopted a new synthesis methods of synthesizing Trazodone hydrochloride, the yield and product content has significantly improved. The product yield improve from 59 percent to 81 percent.Through an experiment, the paper has broken the success of several key steps, which are the synthesis of trazodone hydrochloride, innovative technology for the domestic development of this product to provide a reference. Various polymer products used in the course of the regular are proved to be yellow, cracking, loss of surface gloss, mechanical and electrical properties reducing and finally losing their using value. Agricultural film, plexiglass, light materials, UV resistant coatings, medical plastics, solar energy plastic parts, automotive plastic parts, so on generally added 0.1～0.5% of the optical stabilizer. Benzotriazol is a typical effective optical stabilizer.In this paper, the p-hydroxyphenethyl alcohol and o-nitroaniline are as raw materials, the ultimate goal is completed by diazo coupling reaction,reduction, esterification reaction. Major work is as follows:1: Diazo coupling reaction study is made up, through the improvement of the experimental operation, and ultimately achieved a safe, high-yield the coupling of the product. The product yield improve from 65 percent to 89 percent2: For the reduction of the study, we have used variety of methods to try and compare.3: For the preparation of 2 - (2'-hydroxy-5 '- hydroxy ethyl-phenyl) -2 H-benzotriazole .we have optimized its purification technology, and achieved satisfactory results.