Synthesis Of The Thiazoles Substituted By Ferrocene

In this article, our efforts focused on the synthesis of the thiazoles substituted by ferrocene, which were synthesized by the corresponding thioureas.This article mainly includes two parts. In the first part, ferrocenoyl isothiocyanate was firstly obtained by ferrocenecarboxylic acid. And then a series of chiral thioureas containing ferrocenoyl group substituted were synthesized by the reaction between isothiocyanate and hydrochlorate of some natural amino acid methyl esters. Finally, the thiazoles substituted by ferrocenoyl group were gained by those thioureas reacting with 1-bromopropan-2-one.In part two, different thioureas which were synthesized by ferrocenoyl isothiocyanate reacting with 2-aminopyridin, 2-aminopyrimidin, and 2-aminobenzothia- zole respectively were reacting with iodobenzene diacetate to afford the desirable thiazoles.All of the products were confirmed by IR, NMR, HRMS spectra.