Studies On The Total Synthesis Of Indolizidine 167B And Cremastrine

This thesis main focused on the syntheses of Indolizidine 167B and Cremastrine.Its included the following three parts:Chapter 1.Chemistry of Weinreb amides,and applications in organic synthesis.(review).The preparation of Weinreb amides was introduced in detail.The important applications in organic synthesis were also reviewed.Chapter 2.Synthesis of Indolizidine 167B.The definition,previous synthetic reports of Indolizidine alkaloid were introduced in brief.The precursor of Indolizidine 167B was obtained from Boc-L-proline as starting material via substitution reaction,intramolecular aza-micheal addition reaction and intermolecular micheal addition reactionChapter 3.Synthesis of Cremastrine.The definition,previous synthetic reports of Pyrrolizidine alkaloid were introduced in brief.The approach of synthesis of Cremastrine was studied starting from L-Proline and L-threonine.In which Dieckmann reaction and epoxidation were key steps.