Targeting Transport Properties For The Paramagnetic Nanometers-iron Nuclide Particle

Magnetic targeting of malignant tissue using multifunctional carrier particles has the potential to provide more effective anticancer treatment by enabling a variety of localized treatment and diagnostic modalities, while at the same time reducing undesired side effects. The therapy has become one of the spot of the treatment of toumor. Compareing to the traditional chemotherapeutics and actinotheraphy, targeting therapy avoids the serious side-effect to healthy cells while enhances the medicament density in malignant tissue and increase the treatment effect greatly. For the reasons above, it has important and potential application in the treatment of tumor in future.Recently, a new-style superparamagnetism material with radioactivity named paramagnetic nanometer-iron nuclides (PNINs) has been manufactured successfully by Prof. Xiong-Ping. The radius of the PNINs is about 100 nanometer. It has been proved that the PNINs could be guided to and concentrated at the desired region by mean of a magnetic field positioned outside the body. Hence, traditional chemotherapeutics and actinotheraphy may be enhanced.In order to research an appropriate PNINs targeting system for tumour therapy we studied the collective property of PNINs controled by external magnetic field. According to the magnetic force act on the magnetic drug carrier particles (MDCPs) was depend on both of the intensity and gradient of magnetic field, we compared the distribution of intensity and gradient of three different magnetic field: circular current, Helmholtz loop and cylinder permanent magnet, then we choose the cylinder permanent magnet as the magnetic field for PNINs targeting system. The collection and dynamic action of a single PNINs and PNINs enwraped polymer and anticancer medicament in the human microvasculature were studied numerically. Taking into account the dominant magnetic and fluidic forces on the particles, our study shows that the particles can be directed to and concentrated at the desired zone that within a few centimeters from the surface of the body. In addition, effect of the malignant tissue depth, content of nanometers-iron nuclide in a particle, the blood flow velocity and the radius of the microvasculature on the captured efficiency are parametrically analyzed. These results in the paper are useful for PNINs to clinical application.This paper made up of four chapters, in the first chapter we introduced the general situation, actuality and prospect of MDT; in the second chapter we compared the distributing of intensity and gradient of three different magnetic field: circular current, Helmholtz loop and cylinder permanent magnet; in the third chapter we studied numerically the collection and dynamics action of PNINs in the human microvasculature; in the fourth chapter we summarized our work.