Syntheses, Characterization And DNA-binding Study On Metal-complexes With 7-methoxy-chromone-3-carbaldehyde Hydrazones

Recently, Binding study of small molecules with DNA has long been an important subject in the biochemistry and medicine. It is extremely useful in understanding the drug-DNA interactions, designing new and promising drugs for clinical applications and developing sensitive chemical probes of nucleic acid structure. In this regard, four kinds of Schiff-base ligands derived from 7-methoxychromone-3-carbaldehyde hydrazone and their sixteen metal complexes have been synthesized. This paper is composed of five chapters:In the first chapter, the synthesizing and testing methods, pharmacological functions on some metallic complexes of flavanones were were summarized.In the second chapter, the four Schiff-base ligands derived from 7-methoxychromone-3-carbaldehydeand their metal complexes have been synthesized and characterized on the basis of 1H NMR spectra, elemental analyses, molar conductivities, IR spectra. HL1:7-methoxychromone-3-carbaldehyde-isonicotinoyl hydrazone; H2L2:7-methoxychromone-3-carbaldehyde-(2'-hydroxy) benzoyl hydrazone; H2L3:7-methoxychromone-3-carbaldehyde-(4'-hydroxy) benzoyl hydrazone; HL4:7-methoxychromone-3-carbaldehyde thiosemicarbazide hydrazone.In the third chapter, DNA-binding modes of HL1,H2L2,H2L3 and their rare earth (La3+, Sm3+, Eu3+, Dy3+) complexes were investigated systematically.In the fourth chapter, the antioxdative activities (scavenger effects on O2-·and OH·) of HL4 and their transition metal complexes (Cu2+, Zn2+, Ni2+, Co2+) were investigated in detail.In the fifth chapter, the fluorescent properties of Sm(Ⅲ), Eu(Ⅲ) complexes derived from HL1 and Sm(Ⅲ), Eu(Ⅲ) complexes derived from HL2 were studied.