Study On Synthesis And Methods Of Some New 1,3,4-thiadiazolo[3,2-a] Pyrimidinone And Pyrazoline Derivative

Pyrazole and thiadiazolopyrimidinone derivatives are the compound that has widely biological activities and extensive used to industry, agriculture and medicine field and so on. Because of vast foreground, the compounds are researched by the chemists who were more and more, many novel significant and good biological activities compounds were synthesized. Based on the above-mentioned, some new heterocyclic compounds which contain pyrazole and thiadiazolopyrimidinone nucleus were synthesized and synthesis methods were studied, reaction was researched in this thesis.There are two major parts in this thesis:The first part is about literature review. The research status and development of the 1,3,4-thiadiazolo[3,2-a]pyrimidinone, pyrazole, and KF catalyzed asymmetry 1,4-addition reaction.The second part is about experiment sections. Major work is as follows:1. Some novel 2-substituented-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-ones were synthesized by reaction of intermediate 5-substituted-2-amino-thiadiazole and ethyl cyanoacetate in the P2O5-HCOOH catalyzed with Diversity-Oriented reaction.5-Substituted-2-amino-thiadiazoles were preparated by reaction of carboxylic acid as starting material and thiosemicarbazide under the POCl3. All products were characterized by 1HNMR,13CNMR,MS,IR spectral data, and the crystal structure of two compounds were determined.2. Several new 1-arylaminothiocarbonyl-4,5-dihydro-3,5-disubstitutedpyrazole were synthesized by the reaction of isothiocyanates and intermediate compound which was preparated by the refluence of hydrazine hydrate and a,β-unsaturated ketone from the condensation of ketones as the starting material with aldehydes in ethanol.3.β-Cyanoketone derivatives were given by Michael addition reaction of chalcone derivative as the starting material with malononitrile under the KF/(iPrO)3Al catalysted, and the asymmetric 1,4-addition reaction of cyano to chalcone derivative was preliminary researched under the KF/Al(Ⅲ) salt.