Study On Mesoporous Silica Xerogels Applied For Tissue Repair

In this study, mesoporous silica xerogels applied for tissue repair with disparities of ingredient ratio and heating rate were synthesized by a sol-gel method using surfactant CTAB as the pore-forming agent. It was demonstrated that C40 (prepared with 40 milligram CTAB when the amounts of TEOS and H2O were 300mL and 400mL, respectively) with excellent microscopical structure and surface morphology was non-crystal containing large amount of hydroxyl groups and Si-O bonds.Well ordered calcium-doped mesoporous silica xerogels (m-SXC) was synthesized using surfactant triblock copolymer (P123) as the template agent. Characterization results illustrated that m-SXC with high specific surface area and homogeneous pore size was bioactive. MC3T3-E1 cells culture with materials verified that m-SXC had great biocompatibility. In addition, m-SXC possessed the function to enhance blood clotting sharply promoted with the increase of Ca amounts in m-SXC and materials amount, respectively, which indicated the remarkable hemostatic activity.Copper and siliver-doped mesoporous silica xerogels with ideal microscopical structure were prepared, respectively. Furthermore, no apparent effect of copper element on materials' structure and composition was observed and copper ions could be released from copper-doped mesoporous silica xerogels. Mesoporous silica xerogels containing copper had significant antibacterial properties against E. coli and S. aureus, as well as those containing siliver against E. coli. Besides, we can come to the conclusion that, compared with copper ion, siliver ion performed more effectively antibacterial ability against E. coli. The goal that mesoporous silica xerogels containing siliver had no negative effect on cell viability could be achieved by reducing the siliver content in materials. In vivo wound healing experiment with New Zealand rabbits demonstrated that mesoporous silica xerogels containing copper element could promote the wound healing process.Mesoporous silica xerogels with satisfactory BSA adsorption ability and large diameter (more than 15nm) were synthesized. It is verified that these materials had great biocompatibility without any negative impact on cell attachment and proliferation by MC3T3-E1 cells culture experiment.