Synthesis, Crystal Structure, Interaction With DNA/BSA And Antibacterial Activity Of Lanthanide Complexes With Fluoroquinolone

China is rich in lanthanide reserves and still leads the first in the world. At present, lanthanide has been widely used in metallurgy, petroleum, chemical, textile, medicine, agriculture and other dozens of industries, particularly in biology. Lanthanide ions and their compounds attracted extensive attention because of their significant anti-inflammatory, antibacterium, and other biological activity. As functional metal centers, there has been an upsurge in the use of lanthanide for their fantastic coordination properties and special chemical charactertics arising from 4f electrons and the properties to form isostructural complexes. Quinolones are a kinder of synthetical antibacterial agent which has wide antimicrobial spectrum and strong antibacterial activity. It was mainly used to treat urinary tract, respiratory tract and skin infectious diseases. Their mechanismn was interfering the synthesis of DNA, RNA and protein, destroying the fission of cells in order to sterilize by inhibiting DNA gyrase and topoisomerase. It was different from the old antibacterial agents and antibiotics. Thus, we focused on the study of lanthanide (Ⅲ) complexes with fluoroquinolones, investigated the interaction with DNA/BSA and their antibacterial activity.The main content of this paper:1. Five new lanthanide (Ⅲ) complexes with enrofloxacin, [RE2(ER)6(H2O)2]·14H2O (RE(Ⅲ)=La (Ⅲ), Pr (Ⅲ), Nd (Ⅲ), Sm (Ⅲ), Eu (Ⅲ)) (1)～(5), were synthesized under hydrothermal condition and characterized by means of elemental analysis, FT-IR, TG-DTG and X-ray single crystal diffraction. The interaction with bovine serum albumin (BSA) was studied by UV-vis absorption spectra and fluorescence spectra. Antimicrobial activity was carried out by Oxford cup method.2. Three new complexes with norfloxacin, [N(CH3)4][Nd(NF)4]·6H2O (6), [N(CH3)4][Sm(NF)4]·6H2O (7) and [N(CH3)4][Ho(NF)4]·6H2O (8), were synthesized under hydrothermal condition and characterized by means of elemental analysis, FT-IR, TG-DTG and X-ray single crystal diffraction. The interaction with DNA and bovine serum albumin (BSA) were studied by UV-vis absorption spectra and fluorescence spectra. Antimicrobial activity was carried out by Oxford cup method.3. Two new Mn(Ⅲ) complexes with norfloxacin and ciprofloxacin, [Mn(NF)2(H2O)2](bipy)·4H2O (9) and [Mn(CP)2(H2O)2](bipy)·4H2O (10), were synthesized under hydrothermal condition and characterized by means of elemental analysis, FT-IR and X-ray single crystal diffraction. The interaction with DNA and bovine serum albumin (BSA) were studied by fluorescence spectra and agarose gel electrophoresis.