Synthesis And Antitumor Activity Of Pt Complexes Of Azoles

Azoles is an important class of heterocyclic compounds. Many derivates of them haveapplication in indusry. And in medicine, they show well biological activities in antiviral,antimicrobial, antineoplastic, fungicidal and inhibition of tyrosinase. Therefore, recent years,people pay more attention on the research of azoles. In this article, we synthesized someazoles by conventional methods, besides that, some derivates of azoles have been synthesizedunder solvent-free and catalyst-free conditions. Then, we synthesized platinum complexeswhich using azoles as ligands. We present some results as follows:A series of 2-phenyl-5-aryl-1,3,4-oxadiazole were synthesized by grinding reaction ofbenzoyhydrazide, benzaldehyde and TCCA under solvent-free condition. The reactions werecompleted within 10 min giving the products in 75%~85% yields.The method has theadvantages of simple, rapid and environment friendly. Then synthesized platinum complexes.We used benzaldehyde, benzoyhydrazide and acetic anhydride as starting reagents, synthesized3-acetyl-2-phenyl-5-aryl-1,3,4-oxadiazole by two steps. Then, synthesized platinumcomplexes.We used hydrazine hydrate, carbon bisulfide, acetic acid and aldehyde as starting reagents,synthesized 5-methyl-4-amino-1,2,4-triazole-3-thione Schiff bases. Then synthesized platinumcomplexes.The complexes were characterized and evaluated for their anti-tumor activity against somecancer cells in vitro by MTT method. Among them, complexes 13 and 15 show a certainanti-tumor activity.