Study Of Salen-transition Metal Complexes Synthesis And Interaction With DNA

This paper, based on 2 - hydroxy -1 - naphthaldehyde highly conjugated and rigid naphthalene ring plane larger, It can be formed with the diamine-rich coordination with the characteristics of Schiff base ligand and the singular structure and properties of transition metal Complexes, formed eight Complexes from 2 - hydroxy -1 - naphthaldehyde and o-phenylenediamine, (ethylenediamine, 1,2 - diaminopropane, 1,3 - diaminopropane ) synthesized four Schiff base ligand and its transition metal Mn , Co complexes, In elemental analysis, IR, MS, ICP and other methods characteriz the structure of the complexes. And using UV titration, viscosity, cyclic voltammetry etc study the modes action DNA with complexes, get the following two conclusions:1. When containing naphthalene ring Salen-Mn (â…¢) complexes with DNA compared with Salen-Mn (â…¢) only containing the benzene ring structure easier to combine with DNA, the model is the intercalation, May be the naphthalene ring plane is greater. Also found that because of different bridging groups raised the role of complexes with DNA binding strength of different forces, Binding constants differ.2. Using the same ligand, when Co (â…¢) instead of Mn (â…¢) Synthesis of Salen-Co (â…¢) complexes afect with DNA, Mode of action is also insert mode. And binding constants is larger than the corresponding Mn complex with DNA, For the same ligand complexes with different central ion effect of DNA provides a thought.