Expression Of SASH1 Gene In Esophageal Squamous Cell Carcinoma And Its Clinical Significance

AIM:To explore the expression of the candidate tumor suppressor gene SASH1in human esophageal squamous cell carcinoma (ESCC), and the relationship between its expression and clinical pathology is analyzed.METHODS:The expression of SASH1was detected by immunohistochemistry in72ESCC specimens and40tumor-adjacent specimens.RESULTS:The positive rate of SASH1protein expression in ESCC tissue was significantly lower than the adjacent non-carcinoma tissue (41.67%vs80.00%, P<0.001). The level was higher in group without lymph node metastasis than that in lymph node metastasis group (^=6.583, P<0.05). The expression of SASH1was associated with the tumor differentiation and TNM stage (P<0.05).CONCLUSION:Downregulation of SASH1gene expression is involved in the ESCC. SASH1gene may be a novel candidate tumor suppressor gene in ESCC and can be used as a molecular maker for the diagnosis and treatment of ESCC.