Correlation Of 24 - Hour Pulse Pressure, Cystatin C And Renal Artery Resistance Index In CKD Patients

Objective:Chronic kidney disease (CKD) can be induced by various factors and is aggravating.The insidious onset, poor prognosis make it a global health problem.Pulse pressure reflects the volatility of the blood, and is a reliable indicator to measure the degree of artery stiffness. It has been confirmed that renal resistance index is associated with the prognosis for CKD.Our study is to explore the correlation between24-hour pulse pressure and renal resistive index in CKD patients.Methods:Our study is based on the definition of CKD from K/DOQI guide by Ame-rican kidney foundation (NKF).448patients were chosen as study sample. Measure-ments include the following biochemical index:segmental artery resistive index,24hour pulse pressure, weight, height, renal function, cross product of calcium and phosphoniumet.Results:In our study, renal resistive index is positively correlated with age (r=0.506, P<0.01),UA (r=0.249.P<0.01).Ca×P (r=0.246, P<0.01),24-hPP (r=0.599. P <0.01), and negatively correlated with GFR (r=-0.558, P<0.01).Multivariate logisticregression analysis shows that renal resistive index with24-hPP (P<0.01),GFR (P<0.01).age (P<0.01), hypertension history (P<0.01).use of ACEI or ARB (P<0.05) were independently associated.Conclusion:24-hPP is posistively correlated with renal resistive index in CKD, the higher24-hPP is, the higher the RRI of the patients.It may indicate that large artery elasticity is associated with the prognosis of CKD. Objective:Cystatin C (Cys C) is a cysteine protease inhibitor produced at a constant rate by nucleated cells, filtered through the glomerular membrane and reabsorbed by kidney tubular cells. It suffers little influence of gender and muscle mass, and has been proposed as a sensitive marker for glomerular filtration rate. This study is to explore the correlation between serum cystatin C and renal resistive index in CKD patients.Methods:Our study is based on the definition of CKD from K/DOQI guide made by American kidney foundation (NKF).688patients were chosen for the study. Measurements include the following biochemical index:segmental artery resistive index, serum cystatin C, weight, height, blood pressure, renal function, blood sugar, cross product of calcium and phosphoniumet.Results:In our study, the renal resistive index is positively correlated with age (r=0.487, P<0.01), UA (r=0.243, P<0.01), Ca×P (r=0.204, P<0.01), cystatin C (r=0.518, P<0.01), and negatively correlated with GFR (r=-0.540, P<0.01).Multivariate logisticregression analysis shows that renal resistive index with cystatin C (P<0.01), age (P<0.01), diabetes mellitus history (P<0.01), hypertension history (P<0.01), and use of ACEI or ARB (P<0.05) were independently associated.Conclusion：Serum cystatin C is correlated with renal resistive index independently of GFR in CKD. Patients with higher cystatin C show greater RRI. It may indicate that cystatin C is a better indicator for renal function in CKD than GFR.