| Objective:To explore the influence on vascular endothelial growth factor by TCM Prescription of Yiqi Huoxue Liangxue Shengji (YHLS; i.e. Qi supplementation; blood activation and cooling; and muscle proliferation), observe fluctuation of inflammation level in patients post to intervention therapy and function of YHLS, and discuss whether TCM has functions to improve endothelium and recover inflammation reactions during peri-operative period, thereby exploring the possible mechanism of YHLS to relieve re-stenosis of blood vessels post to intervention therapy and providing a new idea for clinical prevention for and treatment of re-stenosis of blood vessels post to intervention therapy.Methods:(1) We randomized 158 patients who underwent PCI successfully in Cardiac Department of Dongfang Hospital from June 2011 to October 2013 into a treatment group (n=75) and a control (n=83).(2) Since the day of intervention therapy, routine Secondary prevention treatment was launched for patients in both groups, containing Aspirin Enteric-Coated Tablet, Fosinopril Sodium Tablets, Bisoprolol, clopidogrel, a Statins, Low-Molecular Heparin and a Nitrate Esters in dosages adjusted according to onset of angina pectoris. In the background of this routine modern medication, patients in the treatment group started to take the TCM Prescription of YHLS (containing raw astragalus, salvia, honeysuckle flower and moutan cortex) from the day of intervention therapy in a course lasting from the next day after PCI to two months after PCI.(3) 1-year follow up post to intervention was carried out. The primary end points include mainly TCM symptoms and signs integral evaluated at month 12 after medication began; High-Sensitivity C-reactive Protein (hs-CRP) evaluated at month 2 and 12; vascular endothelial growth factor evaluated at month 12; and cardiac-vascular events evaluated at month 12.(4)Statistics:the statistical software of SPSS 17.0 was used. Chi-square analysis and rank-sum test were used for count data, and t-test for quantitative data.Results:(1) General information: 158 patients were recruited in total, including 75 in treatment group and 83 in the control, and all of them underwent PCI successfully.Comparability was proved by statistics between the two groups, without significant difference observed in sex, age, the presence of hypertension, lipid abnormality, diabetes and smoking history, and the status of lesion vessels (P>0.05).(2) Comparison on TCM symptoms and signs integral:at month 12 during the follow up the integral of chest distress, blood stasis, shortness of breath, fatigue or palpitation was better in the treatment group than in the control (P<0.05).(3) Comparison on hs-CRP:at month 2 during the follow up, the level of hs-CRP was significantly lower in the treatment group than in the control (P0.05); at month 12 during the follow up, no significant difference was notice between the two groups (P>0.05).(4) Vascular endothelial growth factor (VEGF):no statistical difference in level of VEGF was observed between the two group before medication (P>0.05), with proven inter-group compatibility. Statistical difference was found at moth 2 and 12 during the follow up (P<0.05), and the treatment group seemed superior to the control in the level of VEGF.Conclusion:(1) TCM Prescription of YHLS may help relieve the symptoms post to PCI, including chest distress, fatigue, shortness of breath and palpitation, and be applied to clinical practice as a basic TCM prescription indicated for coronary heart disease patient with Qi-deficiency and Blood-stasis post to intervention.(2) TCM Prescription of YHLS may lower the level of recent inflammatory factor post to PCI.(3) TCM Prescription of YHLS may increase the level of vascular endothelial, growth factor.
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