| Latent autoimmune diabetes in adult (LADA) is an autoimmune disease a subtype of type 1 diabetes. Its clinical manifestations are divided into two phases:(1)stage non-insulin-dependent (2) insulin dependence. At present domestic main diagnostic criteria: diabetes diagnosis was established, after exclusion of gestational diabetes mellitus and other special type of diabetes, at the same time satisfy the following three items:(1) age> 18 (2) positive islet autoantibodies (3) It is six months at least without relying on insulin treatment after the diagnosis of diabetes. Western medicine is mainly composed of insulin replacement therapy. In the aspect of traditional Chinese medicine according to the characters of its symptoms, it is classified as "Diabetes" category. Under the circumstances of single treatment of western medicine, Chinese medicine has displayed the unique advantages. However, the differentiation of TCM Syndromes of LADA is not clear.[objective] To investigate the characteristics of TCM symptom LADA patients and clustering analysis, and combined with clinical practice and the basic theory of TCM, try to put the LADA symptom clustering analysis, and thus is more objective to classify the disease.[method] (1) To select from 1720 diabetic patients in the hospital of the East hospital endocrine department from March 2012 to March 2015, get 40 LADA patients as the research object. (2) Accordancing to the relevant standards "LADA patients with TCM syndrome questionnaire", we collecte TCM four diagnostic information and the relevant patient data, use SPSS 17.0 software to establish database, input the datas with double method and after checking lock the database. (3) We use SPSS17.0 statistical software for statistical analysis, after reviewing and checking the relevant information of LADA patients (gender, age, height, weight, duration and TCM syndrome characteristics, etc.).The general statistics use frequency statistics.Contrast between groups use the X2 test.Symptom and syndrome distribution use data mining technology such as frequency analysis and cluster analysis.the TCM syndrome of quantitative data conversion to the quantifiable data to explore the shape classification of syndrome of LADA.[results] (1) This study collected 40 patients with all age, but see more between 40 and 69 year-old (X2= 19.7, P= 0.001). There were no differences in the incidence of male and female. (2) This study collected the 40 cases of LADA patients 35.0% with the family history of diabetes,52.5% with smoking history,27.5% with the history of drinking, while only 7.5% overweight patients. (3) Most of the patients in this study were acute diabetes and risk of hypoglycaemia happens. (4) To study the TCM symptoms of 40 patients first frequency analysis, the minimum frequency of 7.5% is more than 5.0% All statistical factors of TCM symptoms are symptoms effectively. The effective symptoms of TCM were systematically clustered, and the process map of the tree cluster analysis was obtained by using Ward clustering method and the two classification of measurement standards.. According to the result of tree diagram by experts in combination with the practical situation of the professional knowledge and clinical analysis, we think it is reasonable to 3 to 7 class. The clustering number prescribed maximum 7 classes, minimum of 3 classes. Same clustering method is used for all patients with cluster analysis, the result shows:When it is divided into six or seven class, a class only have 2 people, less than 10% of the total, the rest of the classification number of each type of 4 or more. Too little for this class of individuals might be one kind split from a broad categories. Calculate the distance between the centers of the cluster size.According to the laws of Bergs abandon 6 and 7 kind of classification method. Adjust clustering number for 3 to 5 classes. Further to all effective TCM syndrome for principal component analysis, the result shows:When three classes, the third class indicators is relatively complex. When it is divided into five types, the first and the second category of indicators are similar, belong to wet.This two kinds of classification methods do not meet the basic theory of TCM. When is divided into four categories, various index is relatively simple. Four taxonomy is quite reasonable.[conclusion] According to TCM syndrome in the 40 cases of LADA, four taxonomy is most reasonable. According to the basis of traditional Chinese medicine and Chinese medicine diagnostics, summarize each kind of main component:stomach fire flaming, water wet stop, gas Yin deficiency of blood stasis and humid connotations. The stomach fire flaming syndrome is the most. |
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