Study On The Correlation Between Obesity / Overweight And Different Physical Types And Vascular Endothelial Dysfunction

Objective:To study the vascular endothelial function in different obesity/overweight individuals divided by constitution of TCM, explore the use of TCM Constitution Identification Criteria for Obesity/Overweight to determine the feasibility of early endothelial dysfunction cardiovascular screening.Methods:Obese BMI criteria select 89 fat person examples, ruled out those have the diseases like diabetes, cardiac insufficiency, coronary heart disease, hypertension, cerebrovascular accident and hepatic and renal dysfunction, and signed informed consent forms. Subjects are divided into four groups:obesity phlegm-dampness group, obesity phlegm-dampness and blood stasis group, obesity qi-deficiency group and balanced group according to TCM Constitution Identification Criteria for Obesity/Overweight. Measuring participants’height, weight, waist circumference, hip circumference, using the InBody770 tester to detect the body fat rate, using Endo-PAT biological sensing system to detect vascular endothelial function (RHI), using the ELISA method to detect Endothelin-1(ET-1), Vascular Endothelial Growth Factor (VEGF) and von Willebrand Factor(vWF).Results:The RHI of obesity phlegm-dampness and blood stasis group is significantly lower than the rest of the three groups, and the difference is statistically significant, there is no significant difference among obesity phlegm-dampness group, obesity qi deficiency group and balanced group;The vWF of obesity phlegm-dampness and blood stasis group is significantly lower than the rest of the three groups, and the difference is statistically significant, there is no significant difference among obesity phlegm-dampness group, obesity qi deficiency group and balanced group;there is no significant difference among the four groups in ET-1 and VEGF.Conclusion:1. Obese people has endothelial dysfunction before metabolic disease occurs; 2. In different types of obesity/overweight individuals divided by constitution of TCM, the type of obesity phlegm-dampness and blood stasis is more likely to have endothelial dysfunction than the other types; 3. vWF can reflect the state of endothelial dysfunction earlier, and the sensitivity is better than ET-1 and VEGF.