Clinical Study On Prevention And Treatment Of Neurotoxicity Induced By Oxaliplatin By

Objective: Research I branch since plans to invigorate the circulation of menstruation soup soak prevention and control of traditional Chinese medicine for external use only oxaliplatin into the curative effect of peripheral nerve toxicity caused by chemotherapy. Observe and analysis the incidence of peripheral nerve toxicity and safety of using hierarchical levels and invigorate the circulation of menstruation of soup, aims to improve patients’ TCM syndrome, improve the quality of life of patients. Materials and methods: Collected from 2013 to 2015 in dalian hospital of TCM oncology within four ward in hospital or outpatient clinic of the chemotherapy regimens including oxaliplatin into the stomach, knot, 55 cases of cancer patients. Divided into two groups with randomized method, the treatment group(27 cases) for chemotherapy patients with soak of TCM for activating blood menstruation soup at the same time, the control group(28 cases) and coupled with warm water soak for chemotherapy patients, compare the incidence of neurotoxicity caused by oxaliplatin into two groups of patients and toxicity grade level, the improvement of TCM syndrome score and improve patient quality of life scores. Result: 1. Compare two groups of patients the incidence of nerve toxicity, caused by oxaliplatin into the treatment group was 48.1%, the control group was 82.1%, the x2 test, P = 0.012(bilateral), P < 0.05, statistically significant differences, has the significance. 2. Compare two groups of patients above Ⅱ degrees peripheral nerve toxicity, among them the occurring rate of treatment group was 11.1%, the incidence was 39.2%, the control group(P < 0.05), the difference is statistically significant; Treatment group Ⅱ magnitude above neurotoxicity of oxaliplatin into cumulative dosage of 1040.5 ± 215.8 mg, control group plus or minus 965.3± 280.2mg, bilateral test P = 0.511 > 0.05, no statistically significant differences between the two groups. 3. Compare two groups of patients with chemotherapy and coupled with huoxue menstruation soup to improve the situation of TCM syndrome after treatment, the treatment group total effective rate was 92.6%, total effective rate was 39.3%, the control group(P < 0.01, significant differences. 4. Compare two groups of patients with chemotherapy and coupled with huoxue menstruation soup on the improvement of their quality of life score after treatment, the treatment group total effective rate was 85.2%, total effective rate was 46.4%, the control group(P < 0.05, there is statistically significant. 5. Safety indexes before and after treatment, two groups of patients with no obvious change, are in a safe range. Conclusion: 1. The soak of TCM for activating blood menstruation soup can prevent and reduce the incidence of peripheral nerve toxicity and toxicity caused by oxaliplatin into hierarchical levels. 2. The soak of TCM for activating blood menstruation soup doesn’t increase occurred Ⅱ degrees above the neurotoxicity of oxaliplatin into use. 3. The soak of TCM for activating blood menstruation soup can improve the syndromes curative effect is distinct 4. The soak of TCM for activating blood menstruation soup can Effectively improve patient quality of life 5 The soak of TCM for activating blood menstruation soup In the clinical study has good security.