Clinical Observation Of Lucentis Combined With Traditional Chinese Medicine In The Treatment Of Ischemic CRVO With ME

The purpose: Ischemic CRVO patients with secondary ME, resulting in eyesight dropped sharply,visual distortion, seriously affect visual function. This research adopts the intravitreal cavity Lucentis joint systemic application of salvianolate in the treatment of ischemic CRVO complicated with ME, aimed to investigate the clinical efficacy of this type of surgery and complications and to explore its possible mechanism of action, and provide reference for clinical applications.Materials and methods:For 2013 l O months to October 2014 were treated 54 cases of 58 based on fundus fluorescein angiography(FFA) results, was diagnosed with ischemic CRVO and associated with ME, were randomly divided into intravitreal Lucentis joint salvianolate salt treatment group 29 cases and intravitreal Lucentis alone 29 cases in the control group,to observed before and after treatment 1w, 2w, 1m, 2m, 3m best corrected visual acuity, intraocular pressure, optical coherence tomography(OCT) changes. 3-month follow-up.Results: 1 vision:( using ETDRS eye chart vision inspection method, recording the largest number of letters can be seen in patients) in the treatment group and the control group therapy after treatment 1w, 2w, 1m, 2m, the mean visual acuity compared with before treatment, the differences were tatistically significant(P <0.05); treatment group and control group after treatment, 1w, 2w, 1m, 2m, compared with before treatment,no significant difference(P> 0.05), the treatment group and 3m compared to the control group after treatment, the difference was statistically significant(P = 0.006 <0.05).2 intraocular pressure: the treatment group and the control group after treatment 1w, 2w, 1m, 2m, 3m IOP compared with the average of the mean IOP before treatment, the difference was not statistically significant(P> 0.05). 3 Central macular thickness: the treatment group and the control group after treatment 1w, 2w, 1m, 2m, 3m, compared with the average of the CMT averages before treatment, the difference was statistically significant(P <0.05); the treatment group and the control group after treatment, 1w, 2w, 1m, 2m, compared with Before treatment no significant difference(P> 0.05), 3m after treatment group compared with the control group, the difference was statistically significant(P = 0.036 <0.05). 4 Treatment group and control group after 3 months of TCM syndrome integral value compared with before treatment, the difference was statistically significant(P < 0.05), Improve TCM syndrome integral situation: the treatment group and control group after treatment of 3 m two group total effective rate of TCM syndrome integral, statistically significant. Treatment group and control group to observe during the period of three months were found 1 cases high intraocular pressure, but no other eye complications occurred in both groups, found no adverse systemic effects associated with the drug.Conclusion: Glass body cavity licensed joint resistance systemic application of salvia miltiorrhiza injection polyphenols acid salt treatment effect is better than that of pure glass body cavity injection of licensed resistance and combination in a short period of time is safe and effective improvement in a long time and steady CRVO patients vision; Can effectively promote the absorption of macular edema: is a method for the treatment of CRVO reliable.