Clinical Study Of CT - Guided Radiofrequency Ablation Of Pulmonary Malignancies

Objective To evaluate the safety and survival rates and local control efficacy of pulmonary malignancies treated with computed tomography(CT)-guided radiofrequency ablation(RFA)for patients with unresectable tumors or those refusing surgical operation.Methods 67 pulmonary malignancies were performed with CT-guided radiofrequency ablation in 67 patients. The mean size of the lesion was 3.1(1.5-.46)cm. According to tumor source, all patients were divided into primary non-small cell lung cancer group(34 patients) and pulmonary metastases group(25 patients). According to the size of the lesion, all patients were divided into small lesion group(32 patients, ≤3cm) and large lesion group(35 patients, 3.1-4.6cm). The overall and cancer-specific survival rates and local progression-free rates were compared between the two groups.Results All the cases were able to complete the radiofrequency ablation under the CT-guidance. During and after the procedure, no major complications occurred. The 1-,2-,and 3-year overall and cancer-specific survival rates and local progression-free rates in the primary non small cell lung cancer group were slightly higher than that in the pulmonary metastases group(the overall survival rates: 92.9%、85.7%、71.4% and 96%、83.5%、58.4%,P=0.31, the cancer-specific survival rates: 97.6%、92.4%、79.6% and 96%、87.3%、74.2%,P=0.56, the The local progression-free rates: 78%、72.8% 、 70.1% and 79.6% 、 70.8% 、 65.3%, P=0.71). No statistically significant differences between the two groups were observed. The 1-,2-,and 3-year overall and cancer-specific rates and local progression-free rates in the small lesion group were significantly higher than that in the large lesion group(the overall rates: 96.9%、90.4%、77.5% and 91.4%、80%、57.1%,P=0.07, the cancer-specific survival rates: 100%、93.3%、86.7% and 94.2%、88%、68.7%, P=0.09, the The local progression-free rates: 84.1%、77.4%、77.4% and 73.5%、67.1%、60%,P=0.15). No statistically significant differrence between the two groups were observed.Conclusions CT-guided RFA is a safe and effective local therapeutic methodand can improve the overall and cancer-specific survival rates and local progression-free rates in the treatment of the pulmonary malignancies in the patients with unresectable tumors or those refusing surgical operation.