Efficacy Of Acupuncture In Improving Clinical Symptoms Of Tourette 's Syndrome

ObjectiveThrough retrieving domestic and overseas published literature about acupuncture treatment of Tourette syndrome randomized controlled trials, depended on Cochrane systematic review methods, systematically evaluated the efficacy and safety of acupuncture for the treatment of Tourette syndrome.MethodsLiterature Retrieval:A comprehensively searchable database: â‘ Chinese Databases:Computer Retrieval China National Knowledge Infrastructure, Wan Fang Database, Chinese Biomedical Literature Database and VIP database; â‘¡Foreign Databases:The Cochrane Library, PubMed,EMBASE;â‘¢Manual searches of Chengdu University of Traditional Chinese library-related information;â‘£with http: //scholar.google.co.uk/for supplementary search, collect acupuncture treatment for Tourette syndrome randomized controlled trials literature.Inclusion:Two reviewers were determined according to inclusion and exclusion criteria included literature, if encountered controversy, the two parties decided to participate in the discussion or a third decided.Data Analysis:A systematic review included studies be evaluated with GRADE Level quality evaluation literature, and through the Cochrane Collaboration dedicated statistical package (Review Manager 5.3.5), qualitative and meta-analysis.Results(1) A total of 14 literatures were included, the total sample size of 908 events, 491 cases in the experimental group, the control group of 417 cases. Grouped according to the intervention, the acupuncture treatment of 8 articles,6 articles of acupuncture combined with the foundation treatment compared with foundation.(2) The main outcome measured with the total efficiency, acupuncture and modern medicine control group (RR=1.20,95% CI [1.10,1.32]), acupuncture and foundation treatment and foundation treatment control group (RR= 1.27,95% CI [1.13,1.43]).(3) Secondary outcome measures:Acupuncture VS Western medicine group was using fixed effects models:Motor tic disorder (MD= 0.45,95% CI [-0.41,1.32]), mixed vocal tic disorder (MD=-2.28,95% CI [-2.69,-1.86]), overall damage (MD =-2.71,95% CI= [-4.48,-0.94]), using a random effects model:Total Severity (MD=-5.62,95% CI [-7.24,-4.00]).Basic therapy and acupuncture treatment group basis was using a fixed effect model:The total severity (MD=-7.26,95% CI [-8.81,-5.71]), motor tic disorder (MD=-2.08,95% CI [-2.88,-1.27]), mixed vocal tic disorder (MD=-1.96,95% CI [-2.95,-0.97]).(4) Non-merger outcome TCM Tic Symptom Table scores, scoring five basic tic disorder, pharmacodynamics index of plasma DA and 5-HT qualitative analysis to improve the situation.Conclusions(1) Based on fundamental treatment, acupuncture can collectively improve the clinical efficiency, relieving tic disorders, motor tic disorder, mixed vocal tic disorders. The quality of evidences is moderate grade. Total Severity which quality of evidence is lower, not recommended;(2) Acupuncture can increase Tourette syndrome total effective than medicine. The quality of evidences is moderate grade.(3) Acupuncture in improving Tourette YGTSS Scale total score and movement disorders, mixed dysphonia more advantages than medicine. The quality of evidences is low or lower grade.(4) Acupuncture therapy to improve TCM Tic Symptom Table scores, scoring five basic tic disorder, pharmacodynamics index of plasma DA and 5-HT, adverse effects on the advantages of the future could be further studied.