Synthesis And Synthesis Of 8 - Hydroxyimidazo [1,2 - α] Pyridine - 3 - Carboxylate Compounds

Biological characteristics of the influenza virus and application of the influenza vaccine are briefly described. We focus largely on the development of anti-influenza agents.5-hydroxyl-lH-indole-3-carboxylates have been reported to have potent antiviral activity and Abidol hydrochloride, which inhibits the replication of influenza viruses through the activation of 2,5-oligoadenylate synthetase,has been used against influenza viruses of the A and B antigenic types.Based on the structure-activity relationship of 5-hydroxyl-1H-indole-3-carboxylates, taking Abidol hydrochloride as the lead compound, we change the indole ring into the imidazo[1,2-α] pyridine ring. Thus,8-hydroxylimidazo[1,2-α]pyridine-3-carboxylates are designed and modifi-cations are made at the 2 position and 7 position.16 new compounds are synthesized and their structures are confirmed by LC-MS,some compounds are confirmed by 1H-NMR and IR.