A Pilot Study On The Correlation And It's Mechanism Of The Heart Blood Stasis Syndrome In Coronary Heart Disease And Individual Personality,mental State

A pilot study on the correlation and it's mechanism of the heart blood stasis syndrome in coronary heartdisease and individual personalitymental stateABSTRACTIn these years, along with advancement of the research of modernization of TCM, the study on the heart blood stasis syndrome of coronary heart disease (CHD) have made great progress . But ancient works were mainly focused on the microcosmic diagnosis and macrocosmic quantitative diagnosis. At the same time, accompany with the medical mode changing to bio-psychosocial mode, more and more studies show that mental factors have a significant effect on the occurence * development and prognosis of disease .Heart blood stasis is the most common syndrome of coronary heart disease (CHD). So we want to use modern mental measuring scales to find out the correlation of the heart blood stasis syndrome in CHD and the individual personality the mental state of the patient, and to discuss it's mechanism in the "nerves-endocrine-immunity"network.In the first part of this article, we first reviewed the ancient opinion of the "heart blood"and the "heart blood stasis" It's also expounded that the modern research of the heart blood stasis syndrome in CHD which was mainly focused on the microcosmic diagnosis and macrocosmic quantitative diagnosis. Following that, we stressed on the correlation of the emotional theory of TCM and the modern psychology.To find out the correction , 106 patients with CHD ~vere involved to the investigation with Eysenck Personality Questionaire (EPQ) and Symptom Check-List 90 (SCL-90) including the heart blood stasis syndrome group (59 cases) and non- heart blood stasis syndrome group (47 cases). The EPQ results showed that E-scales (extroversion and introversion) and N-scales (neuroticism) in heart blood stasis syndrome group were higher than the control group and the routine mode (P<0.05-0.0l)~ and most of their temperament types were choleric (49.15%)~ which indicated the patient抯 individual personality with heart blood stasis syndrome were extroversion emotional instability sensitivity and easy to impulse~ With regard to the mental state the SCL-90 showed that the scales of the factors such as depressions anxiety and insomnia of heart blood stasis syndrome of CHD were much higher than that of non-heart blood stasis syndrome and routine mode (P<0.01-0.001). Furthermore, the patients of 30-49 years old had a obviously difference from the patients who were old than 70, and that patients who have a culture degree than university also had this characteristic , which indicated that the patients with CHD in different syndromes different ages and different culture degree have different mental state.To find out the mechanism of these correlation , we choosed the Serum Superoxide Dismutase (SOD), Lipid Peroxides (LPO), Glutathione Peroxedase (GSI-I-Px) and Soluble Interleukin-2 Receptor (SIL-2R) for observation index. Seventy patients with CHD and 30 normal control casese were tested. The results showed (1) The serum degree of SIL-2R of CHD group with the heart blood stasis syndrome were much higher than those of control group (P<0.0 1); (2)In the CHD group , the degree of SOD and GSH-Px~vere much lower than those of control group, and the group with the heart blood stasis syndrome have a more apparent difference of this. These results indicate that the abnormal increase of Oxygen Free Radical and the turblance of immunity play an important role in the pathogenesis of CHDI and different syndromes have their individual characteristic...