| Modern medical research indicated that the mechanism gastric mucosal protection is affected by many factors which include gastric mucosal blood flow (GMBF), prostaglandin ,gastrointestinal hormones and Oxygen free radical . These factors are in line with this pathophysiologic process. It has been reported in many clinical studies that electroacupuncture(EA) can protect gastric mucosa Nevertheless, its mechanism is still unknown. By synchronic observation of the changes in the gastric mucosal histopathology, GMBF, contents of hormones, and Oxygen free radical treated with EA different acupoints and different times in stress rats , we investigate the EA's protective effect on gastric mucosa and its mechanism , as well as its potential scientific implication for clinical application. METHODS The restrain old stress method was used to making stress Supported by the National Science Foundation of China, NO. 39970888 model. By light microscope, JEM 000EX electron microscope, Laser Dopper lowmeter, radioimmunoassay and biochemical methods, we simultaneous assay of the changes in gastric mucosal histopathology, GMBF, contents of hormones in plasma including NO, El EGF, CGRP, PGE2 ,SOD,MDA in stress rats with EA stimulation RESULTS 1. Stress ulcer model of rats is established successfully. 2. In the stress group , ulcer index (UI) of remarkably higher than that in the control group, the damage of gastric mucosal was serious under light and electron microscope, its GMBF and contents of NO, EGF, PGE2, SOD in plasma were apparently lower than those in the control group (1<0.01:0. 05) , but ET, MDA were conspicuously higher than those in the control group (P |
PDF Full Text Request