Study On The Correlation Of Interleukin 6,8 And Tumor Necrosis Factor-alpha Levels In Serum And Peritoneal Fluid With The Pathogenesis Of Endometriosis

Objective To investigate the levels of interleukin 6, 8 (IL-6, IL-8) and tumor necrosis factor-alpha(TNF- a) in serum and peritoneal fluid(PF) of patients with endometriosis(EM) and the role on pathogenesis of EM. Methods 11-6, IL-8 and TNF- a contents in serum and PF of 58 cases with EM were detected by enzyme linked immunoabsorbent assay and compared with the counterparts of 15 cases without EM(Controls). The correlation analyses between IL-6, IL-8, TNF- a concentrations in serum and PF of EM patients and severity of EM were performed. Results The serum and PF from patients with EM contained significantly greater amounts of JL-6(serum:32.77?15.23 pg/mI; PF:126.79?184.55 pg/mI).. IL-8(serum: 53.39?3.45 pg/mi, PF: 155.66?190.99 pg/mI).. TNF-a (Serum: 31.09?19.29 pg/mI, PF: 35.92? 22.03 pg/mI)than those in controls(Seruni: 17.59?.97 pg/mb. 18.15 ?.38 pg/mi.. 11.15 ?3.7lpg/ml; PF: 21.51 ?8.44pgIml, 20.15 ?6.38pg/ml, 12.53 ?7.lSpgImI, respectively)(P<0.0 1). The highest serum and PF IL-6, IL-8, TNF- a concentration were found in stage J1I桰V. Except PF IL-8(r=0.249, P>0.05), significant parallel relationship existed between the stages of EM and the IL-6, IL-8 and TNF- a levels in serum and PF in EM patients(r values: serum: 0.543, 0.427, 0.793; PF 0.695, 0.838, P<0.05?.001). There were significantly higher levels of IL-6~ IL-8 in PF than in serum of patients with EM(p抸0.0l?.05), but no difference was found in TNF- a between 2 serum and PF (p>O.05). Conclusion Unusual levels of IL-6, IL-8, and TNF- U Levels in serum and PF account for imbalance of the immunologically dynamic environment in serum and pentoneal cavity of EM patients, which may be the cause of pathogenesis of EM.