| ABSTRACTClinicaI and ExperimeotaI Study on Effect of HerbFangduIing fOr the Treatment and Prevention of ReccurrentInfectiou8 Herpes Keratiti8Herpes simplex keratitis (HSK) is a significant cause ofcorneal blindness. some oculists reported that HSK is the mostdiseases at corneal in the rccent ten ycars. Becausc recurrences ofit contines and it resists drugs, HSK is the most diffcut fOroculists. Now there are many methods fOr HSK, but they don'tprevent and control HSK. Becausc theory of latency andrecurrence isn't fOund, there has no better methods that canprevent and control HSK. In this research. we evaluated the effectof herb fangduling soup on treating HSK in acut inflammation andthe effect of herb fangdullng pill on prevention HSK in chronicinflammation, and we undertook experiment on mice to observeacute toxicity offangdullng pill.Part I Li terature ResearchWe Summari ed the evo1ve on name, etiology, pathogenesi s,prevention and contro], Lreat, herbs and experimon L of llSKin 1'radi tional Chinese Modicine (TCM). Accordi ng to i t'ssymptoms and signs, IlSK belongs to the category of"Jux inKzhang"j n TCM. The pathogenesi s of llSK are fenA, reshi and, yiBxu, et al. We a1so summaried the evo1ve onopi dem io1ogy, pathogenes is, d iagnosi s, provent ion andcon trol, and cxp1 ored the prob1 om and tendency developmentof HSK.PHrt II Cl i n i c Re 8earchPurpose:4fangdiIing pi l l therapy i n reducing recurrence of herpessimplex kerat i t is (HSK).Methods: Seventy pat ieflts (78eyes) wi th a history offrenquent 1 y recurr ing HSK werc fo l 1owed random1 y into twogroups: (l ) Group l: For.ty pat ients (46eyes) were treatedw ith ftingdu1fng soup comb i ned w i th fangdulingeyedrop. (2) Group2: Th irty pat ients (32eyes) were treatedw i th dcyc 1ov ir eyedrop. l'he pat ients treated compete l ywere fo11owed dgai n, Therapy group: Tirty--e ightpat ien ts (44eyes) werc treated wi th oral fangduIingpi 11; control group: twenty--six pat ients (28eyes) weretreated wi th acyc lovi r eyedrop. they were fol lowed l2--60months, mean 26. 3f l3. 98 months.Resu 1 ts: (l ) Accoding to di fferentia1 diagnos is,ganJingf'engre accoun t s 36. 57%, yinxuxiei iu accoun t s3 1. 43%, shfreneiyun accounts l 5. 7l %, ganhuochfsheng;lc c o [l n t s l 4. 29%.(2) 0uring inducements of HSK, cold and t'ever accounts35. 7l%, overw()rked accounts l8. 57%, menst ruat ion accountsl0%, t'actor ot di et accounts 7. l4%, injury of eye accounts4. 29%, use hormone accounts 2. S6%.(3 ) The efficiency of dendritic keratitis in group l is betterthan it in group 2. The ratio of efficiency of group l is l00%,butthat of group 2 is 88.24%.The time of cure in goupl is 7.58 l l. 66days, but that of cure group 2 is l0. 11 l 4. 5l days. Theeffect of gr()up 1 is better than group 2 (t=--2. 32, P <0. 05). The effciency of geographic keratitis in group l is betterthan it in group 2.The ratio of efficiency of group l is 94.44%,butthat of group 2 is 83.33%. The time of cure in goupl is l8.58i,3. 21 days, but that of cure group 2 is 25. 30l7. 28 days. Theeffect of group l is better than group 2 (t=--2. 40, P r0. 05). Because the case of disci form kerat it is andkertoirt is are few, there are no re1at ively signficancebetween two groups. The vi s ion of pat ients was improve afterthe patients treated in two groups. During 20 patienLs,IgG' IgM' CIl,, were improved after they were treated (Pwt 0. 05) i IgA' IgE. C, weren' t improved after they were treated(P> 0. 05). During l0 pat ients, inter1eukin-- Il was improvedafter they were treated (t=3. 605, Pr 0. 05).(4) The rat io of recurrencc at therapy group is l3. 64%,but that at control group is 35. 7l%. The therapy group isbetter than the control group (x2= 4.83, P< 0.05).After therecover per iod, Lhere is no relat ively signficance betweentherapy group and control group in the first year, but thereis re1... |
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